Plasma levels of inorganic sulfates in patients with Parkinson's disease
| Autor: | C. J. Mateos-Vega, J. Benito, M. V. Aguilar, F J Jiménez-Jiménez, María José González-Muñoz, A. Vazquez, M.C. Martínez-Para, F. Cabrera-Valdivia, A. Jorge-Santamaría, Lucía Ayuso-Peralta, J.A. Molina |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Central nervous system disease chemistry.chemical_compound Degenerative disease Internal medicine Blood plasma medicine Humans In patient Sulfate Aged Sulfates business.industry Parkinson Disease General Medicine Plasma levels Middle Aged medicine.disease Endocrinology Neurology chemistry Spectrophotometry Female Neurology (clinical) business Psychomotor Performance Pharmacogenetics |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1995.tb00148.x |
| Popis: | Some investigators reported pharmacogenetic differences in the metabolism of sulfur-containing drugs and lower plasma sulfate levels in patients with Parkinson's disease (PD) compared with controls. However, other group did not confirm these findings. We studied the plasma levels of sulfate by indirect atomic absorption spectrophotometry in 55 PD patients and 57 age and sex-matched controls. The plasma sulfate levels did not differ significantly between PD patients and control groups (mean +/- SEM 73 +/- 8 and 75 +/- 7 mg/l, respectively). They were not influenced by antiparkinsonian drugs and they did not correlate with age at onset, duration, Hoehn & Yahr staging or activities of daily living subscale of the Unified Parkinson's disease rating scale. There was a low but significant correlation of plasma sulfate levels with motor examination (r = -0.39, p < 0.05) and total score (r = -0.33, p < 0.05) of this scale in the PD group. These data suggest that plasma sulfate levels are apparently unrelated with the risk for PD. |
| Databáze: | OpenAIRE |
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