Pleiotropy of Type 2 Diabetes with Obesity
| Autor: | Swapan K Das, Steven C. Elbein, Sandra J. Hasstedt, Craig L. Hanis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
endocrine system diseases Genetic Linkage 030209 endocrinology & metabolism Type 2 diabetes Biology Article 03 medical and health sciences 0302 clinical medicine Waist–hip ratio Pleiotropy Risk Factors Genetics Genetic Pleiotropy medicine Humans Obesity Genetics (clinical) Abdominal obesity 030304 developmental biology 2. Zero hunger 0303 health sciences Waist-Hip Ratio nutritional and metabolic diseases Odds ratio medicine.disease Diabetes Mellitus Type 2 Chromosomes Human Pair 1 Female medicine.symptom Lod Score Body mass index |
| Zdroj: | Journal of human genetics |
| ISSN: | 1435-232X 1434-5161 |
| Popis: | The risk of type 2 diabetes (T2D) increases with obesity. One possible explanation is that pleiotropic genes affect risk of both T2D and obesity. To identify pleiotropic genes, we performed bivariate analysis of T2D with waist–hip ratio (WHR) and with body mass index (BMI) in the African-American subset of the Genetics of NIDDM (GENNID) sample. Of 12 T2D loci identified through suggestive or higher univariate logarithm of the odds ratio (lod) scores, we inferred pleiotropy with obesity for six (chromosomes 1 at 17–19 Mb, 2 at 237–240 Mb, 7 at 54–73 Mb, 13 at 26–30 Mb, 16 at 26–47 Mb and 20 at 56–59 Mb). These findings provide evidence that at least some of the co-occurrence of obesity with T2D is because of pleiotropic genes. We also inferred four obesity loci through suggestive or higher lod scores for WHR (chromosomes 1 at 24–32 Mb, 2 at 79–88 Mb, 2 at 234–238 Mb and 3 at 148–159 Mb). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|