Thyrotropin receptor antibody activities significantly correlate with the outcome of radioiodine (131I) therapy for hyperthyroid Graves' disease
| Autor: | Kazuro Kaise, Kaoru Yoshinaga, Hiroshi Fukazawa, Makiko Yamamoto, Toshiro Sakurada, Katsumi Yoshida, Koki Mori, Shintaro Saito, Nobuko Kaise |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases medicine.medical_treatment Graves' disease Thyroid Gland Thyrotropin Trab Gastroenterology Iodine Radioisotopes Endocrinology Internal medicine Medicine Humans Euthyroid Life Tables Aged Autoantibodies biology business.industry Thyroid General Engineering Radioimmunoassay Organ Size Middle Aged medicine.disease Graves Disease Radiation therapy medicine.anatomical_structure Treatment Outcome biology.protein Triiodothyronine Female Antibody business hormones hormone substitutes and hormone antagonists Hormone Immunoglobulins Thyroid-Stimulating |
| Zdroj: | Endocrinologia japonica. 38(4) |
| ISSN: | 0013-7219 |
| Popis: | The outcome of 131I therapy for 109 patients with Gravest disease was analysed according to pretreatment laboratory data including thyrotropin receptor antibody (TRAb) activities. Forty-five percent of patients became euthyroid, and 13% of patients became hypothyroid within one year after 131I therapy. Forty-two percent of patients remained hyperthyroid one year after 1311 therapy. Pretreatment values for serum T4, T3, and the estimated weight of the thyroid were significantly higher in the hyperthyroid group. The mean for the TRAb index of the hyperthyroid group was significantly higher than that of the euthyroid group. Life table analysis revealed a significant effect of the TRAb index on the rate of hyperthyroidism after 3 months or later. These results appear to suggest that the TRAb index is one of the factors which influence the outcome of 131I therapy for Graves' disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|