| Autor: |
Petr G. Lokhov, Ipatova, O. M., Abakumova, O. Y., Tsvetkova, T. A., Prozorovskii, V. N. |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| ISSN: |
0929-8665 |
| DOI: |
10.2174/092986650703221206121855 |
| Popis: |
Abstract: An apolipoprotein E 139-158 synthetic peptide was tested for targeting lipid particles to lipoprotein receptors. It was shown that this peptide increases lipid particle binding followed by receptor-mediated endocytosis by cells. In addition, the peptide mediates both acute clearance of lipoproteins followed by the decrease of cholesterol level in a rat blood and acute uptake of liposomes by the tissues which have a high level expression of lipoprotein receptors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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