Rapid sensing and imaging of methylglyoxal in living cells enabled by a near-infrared fluorescent probe

Autor:	Hai Xu, Xin-Rong Liu, Zheng-Hong Cai, Jianfeng Zheng, Ya-Wen Wang, Yu Peng
Rok vydání:	2022
Předmět:	Optical Imaging Organic Chemistry Humans Physical and Theoretical Chemistry Magnesium Oxide Pyruvaldehyde Biochemistry Fluorescent Dyes HeLa Cells
Zdroj:	Organic & Biomolecular Chemistry. 20:4782-4786
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d2ob00698g
Popis:	A novel near-infrared fluorescent probe (SWJT-2) has been designed and synthesized for the detection of methylglyoxal (MGO). It showed a low detection limit (0.32 μM), high selectivity and the fastest detection (15 min) over various reactive carbonyl compounds in aqueous solution. SWJT-2 had been successfully applied to bioimaging in HeLa cells to detect exogenous and endogenous MGO.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef74232e3b19c4eef1f0e6603dad073 https://doi.org/10.1039/d2ob00698g Zobrazit plný text záznamu