Towards resolving the transcription factor network controlling myelin gene expression
| Autor: | Alan C. Peterson, Wyeth W. Wasserman, Hana C. Friedman, Debra L. Fulton, Eric Denarier |
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| Přispěvatelé: | Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics-University of British Columbia (UBC), Department of Oncology [Montréal], McGill University = Université McGill [Montréal, Canada], Department of Human Genetics [Montréal], Department of Neurology and Neurosurgery, ANTE-INSERM U836, équipe 1, Physiopathologie du cytosquelette, McGill University = Université McGill [Montréal, Canada]-McGill University = Université McGill [Montréal, Canada]-Department of Human Genetics [Montréal], McGill University = Université McGill [Montréal, Canada]-Department of Oncology [Montréal], Canadian Institutes of Health Research, Multiple Sclerosis Society of Canada, CEA, Genome Quebec and Genome Canada, Andrieux, Annie |
| Rok vydání: | 2011 |
| Předmět: |
Gene regulatory network
Computational biology Biology Gene Regulation Chromatin and Epigenetics 03 medical and health sciences Myelin Mice 0302 clinical medicine Prosencephalon Genes Reporter [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Genetics medicine Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Gene Regulatory Networks [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Promoter Regions Genetic Gene Transcription factor Conserved Sequence Myelin Sheath [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM] 030304 developmental biology Regulation of gene expression 0303 health sciences [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] Base Sequence Gene Expression Profiling Optic Nerve [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] Oligodendrocyte Gene expression profiling Oligodendroglia medicine.anatomical_structure Enhancer Elements Genetic Gene Expression Regulation Neuroglia [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Nucleic Acids Research Nucleic Acids Research, Oxford University Press, 2011, 39 (18), pp.7974-91. ⟨10.1093/nar/gkr326⟩ |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | International audience; In the central nervous system (CNS), myelin is produced from spirally-wrapped oligodendrocyte plasma membrane and, as exemplified by the debilitating effects of inherited or acquired myelin abnormalities in diseases such as multiple sclerosis, it plays a critical role in nervous system function. Myelin sheath production coincides with rapid up-regulation of numerous genes. The complexity of their subsequent expression patterns, along with recently recognized heterogeneity within the oligodendrocyte lineage, suggest that the regulatory networks controlling such genes drive multiple context-specific transcriptional programs. Conferring this nuanced level of control likely involves a large repertoire of interacting transcription factors (TFs). Here, we combined novel strategies of computational sequence analyses with in vivo functional analysis to establish a TF network model of coordinate myelin-associated gene transcription. Notably, the network model captures regulatory DNA elements and TFs known to regulate oligodendrocyte myelin gene transcription and/or oligodendrocyte development, thereby validating our approach. Further, it links to numerous TFs with previously unsuspected roles in CNS myelination and suggests collaborative relationships amongst both known and novel TFs, thus providing deeper insight into the myelin gene transcriptional network. |
| Databáze: | OpenAIRE |
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