Effect of non-sedation on physical function in survivors of critical illness - A substudy of the NONSEDA randomized trial
| Autor: | Jørgen Lauridsen, Gisela Sjøgaard, Hanne Irene Jensen, Palle Toft, Thomas Strøm, Helene K. Nedergaard, Hanne T. Olsen |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Activities of daily living Critical Illness Sedation medicine.medical_treatment Physical function Critical Care and Intensive Care Medicine law.invention 03 medical and health sciences 0302 clinical medicine Quality of life Randomized controlled trial law Activities of Daily Living medicine Humans Survivors Lead (electronics) Mechanical ventilation Hand Strength business.industry 030208 emergency & critical care medicine Intensive Care Units 030228 respiratory system Critical illness Quality of Life Physical therapy medicine.symptom business |
| Zdroj: | Nedergaard, H K, Jensen, H I, Olsen, H T, Strøm, T, Lauridsen, J T, Sjøgaard, G & Toft, P 2021, ' Effect of non-sedation on physical function in survivors of critical illness-A substudy of the NONSEDA randomized trial ', Journal of Critical Care, vol. 62, pp. 58-64 . https://doi.org/10.1016/j.jcrc.2020.11.017 |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2020.11.017 |
| Popis: | PURPOSE: Critical illness impairs physical function. The NONSEDA trial was a multicenter randomized trial, assessing non-sedation versus sedation during mechanical ventilation. The aim of this sub-study was to assess the effect of non-sedation on physical function.METHODS: All patients from one NONSEDA trial site were included. At ICU discharge and three months thereafter, survivors were assessed for physical function.RESULTS: 205 patients were included, 118 survived to follow-up, 116 participated (98%).PRIMARY OUTCOME: Three months after ICU-discharge, health-related quality of life (SF-36, physical component score) was similar (non-sedated 38.3 vs sedated 36.6, mean difference 1.7, 95% CI -1.7 to 5.1), as was function in activities of daily living (Barthel Index, non-sedated 19.5 vs sedated 18, median difference 1.5, 95% CI -0.2 to 3.2).SECONDARY OUTCOMES: Non-sedated patients had a better Barthel Index at ICU-discharge (median 9 vs 4, median difference 5, 95% CI 2.5 to 7.5). At three months post-ICU discharge, the two groups did not differ regarding handgrip strength, walking distance, muscle size or biomechanical data.CONCLUSION: Non-sedation did not lead to improved quality of life regarding physical function or better function in activities of everyday living. Non-sedated patients had a better physical recovery at ICU discharge.TRIAL REGISTRATION: Clinicaltrials.govNCT02034942, registered January 14., 2014. |
| Databáze: | OpenAIRE |
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