Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective
| Autor: | Zhi-Feng Zhou, Huang Kuang, Yu-Ge Zhu, Shu-Long Yang, Mei-wen Yang, Zhi-Kai Wan, Fen-fang Hong |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
neuronal apoptosis Disease Review Bioinformatics medicine.disease_cause Vascular dementia central cholinergic system Pathology and Forensic Medicine neuroinflammation 03 medical and health sciences 0302 clinical medicine pharmacological treatment parasitic diseases medicine Dementia oxidative stress cardiovascular diseases Neuroinflammation synaptic plasticity business.industry Cell Biology medicine.disease Pathophysiology 030104 developmental biology Synaptic plasticity Etiology Neurology (clinical) Geriatrics and Gerontology biological phenomena cell phenomena and immunity business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Aging and Disease |
| ISSN: | 2152-5250 |
| Popis: | Vascular dementia (VaD) is a neurodegenerative disease, with cognitive dysfunction attributable to cerebrovascular factors. At present, it is the second most frequently occurring type of dementia in older adults (after Alzheimer's disease). The underlying etiology of VaD has not been completely elucidated, which limits its management. Currently, there are no approved standard treatments for VaD. The drugs used in VaD are only suitable for symptomatic treatment and cannot prevent or reduce the occurrence and progression of VaD. This review summarizes the current status of pharmacological treatment for VaD, from the perspective of the molecular mechanisms specified in various pathogenic hypotheses, including oxidative stress, the central cholinergic system, neuroinflammation, neuronal apoptosis, and synaptic plasticity. As VaD is a chronic cerebrovascular disease with multifactorial etiology, combined therapy, targeting multiple pathophysiological factors, may be the future trend in VaD. |
| Databáze: | OpenAIRE |
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