Hypochlorite converts cysteinyl-dopamine into a cytotoxic product: A possible factor in Parkinson's Disease
| Autor: | Meredith M. Njus, Ashraf H. Saleh, Karen A. Beningo, David Njus, Karam Asmaro, Nihar J. Mehta, David J. Hermiz |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell Survival Taurine Dopamine Hypochlorite medicine.disease_cause Models Biological PC12 Cells Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Superoxides Physiology (medical) medicine Animals Humans Peroxidase chemistry.chemical_classification Reactive oxygen species biology Cytotoxins Superoxide Dopaminergic Parkinson Disease Rotenone respiratory system Hypochlorous Acid Rats respiratory tract diseases Oxidative Stress 030104 developmental biology chemistry Myeloperoxidase biology.protein lipids (amino acids peptides and proteins) Oxidation-Reduction hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Free Radical Biology and Medicine. 101:44-52 |
| ISSN: | 0891-5849 |
| Popis: | The dopamine oxidation product cysteinyl-dopamine has attracted attention as a contributor to the death of dopaminergic neurons in Parkinson's disease. Treatment of cysteinyl-dopamine with hypochlorite yields an even more cytotoxic product. This product has potent redox-cycling activity and initiates production of superoxide in PC12 cells. Taurine, which scavenges hypochlorite, protects PC12 cells from cysteinyl-dopamine but not from the hypochlorite product, suggesting that the product, not cysteinyl-dopamine itself, is toxic. Furthermore, rotenone, which enhances expression of the hypochlorite-producing enzyme myeloperoxidase, increases the cytotoxicity of cysteinyl-dopamine but not of the hypochlorite product. This suggests that dopamine oxidation to cysteinyl-dopamine followed by hypochlorite-dependent conversion to a cytotoxic redox-cycling product leads to the generation of reactive oxygen species and oxidative stress and may contribute to the death of dopaminergic neurons. |
| Databáze: | OpenAIRE |
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