Choroidal involvement in Rosai-Dorfman disease successfully treated with cobimetinib
| Autor: | Giuseppe Giuffrè, Chiara Giuffrè |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
choroidal thickness
medicine.medical_specialty medicine.medical_treatment Disease Case Reports Targeted therapy chemistry.chemical_compound lcsh:Ophthalmology Choroidal biopsy Cobimetinib Biopsy medicine Rosai–Dorfman disease MEK inhibitor medicine.diagnostic_test business.industry medicine.disease Dermatology eye diseases Ophthalmology chemistry lcsh:RE1-994 Visual function Etiology sense organs Rosai-Dorfman disease business |
| Zdroj: | Indian Journal of Ophthalmology Indian Journal of Ophthalmology, Vol 68, Iss 9, Pp 2051-2053 (2020) |
| ISSN: | 1998-3689 0301-4738 |
| Popis: | Rosai- Dorfman disease (RDD) is a rare systemic pseudo-lymphomatous disorder with unknown etiology. No guidelines exist regarding its management and treatment when the disease is progressing. Choroidal involvement in RDD has rarely been reported and has often been misdiagnosed. We describe a case of a 64-year-old male diagnosed with RDD by means of choroidal biopsy, successfully treated with a MEK inhibitor, namely Cobimetinib, and its follow-up over 5 years, with good final anatomical and functional results. This is the first reported case of RDD diagnosed with an intraocular biopsy performed on a non-enucleated globe, thus preserving the integrity and function of the eye. This case emphasizes the need for a choroidal biopsy when the diagnosis is not straightforward and the starting of targeted therapy to retain a good visual function. |
| Databáze: | OpenAIRE |
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