Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics Approach
| Autor: | Alaa Shafie, Farah Anjum, Purva Asrani, Yash Mathur, Mohd Umair, Md. Imtaiyaz Hassan, Taj Mohammad, Dharmendra Kumar Yadav, Insan Habib, Arunabh Choudhury |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Proteomics viruses Immunology Genomics Computational biology severe acute respiratory syndrome coronavirus-2 Biology medicine.disease_cause Microbiology Pathogenesis chemistry.chemical_compound coronavirus disease 2019 Cellular and Infection Microbiology RNA polymerase medicine Humans Coronavirus Original Research Comparative genomics chemistry.chemical_classification Mechanism (biology) SARS-CoV-2 SARS-CoV-2 pathogenesis COVID-19 QR1-502 Infectious Diseases chemistry SARS-CoV-2 mutations Spike Glycoprotein Coronavirus Glycoprotein single amino acid substitutions |
| Zdroj: | Frontiers in Cellular and Infection Microbiology Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
| ISSN: | 2235-2988 |
| Popis: | A continual rise in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease (COVID-19) has become a global threat. The main problem comes when SARS-CoV-2 gets mutated with the rising infection and becomes more lethal for humankind than ever. Mutations in the structural proteins of SARS-CoV-2, i.e., the spike surface glycoprotein (S), envelope (E), membrane (M) and nucleocapsid (N), and replication machinery enzymes, i.e., main protease (Mpro) and RNA-dependent RNA polymerase (RdRp) creating more complexities towards pathogenesis and the available COVID-19 therapeutic strategies. This study analyzes how a minimal variation in these enzymes, especially in S protein at the genomic/proteomic level, affects pathogenesis. The structural variations are discussed in light of the failure of small molecule development in COVID-19 therapeutic strategies. We have performed in-depth sequence- and structure-based analyses of these proteins to get deeper insights into the mechanism of pathogenesis, structure-function relationships, and development of modern therapeutic approaches. Structural and functional consequences of the selected mutations on these proteins and their association with SARS-CoV-2 virulency and human health are discussed in detail in the light of our comparative genomics analysis. |
| Databáze: | OpenAIRE |
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