Hepatic artery thrombosis versus neurological complications – Role of antiplatelet medications in adult living donor liver transplantation
| Autor: | Subash Gupta, Neerav Goyal, Naganathan Selvakumar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Surgery Subgroup analysis Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Platelet Antiplatelets Transplantation Kidney Aspirin business.industry Living donor liver transplantation Case-control study lcsh:RD1-811 Clopidogrel medicine.disease Surgery Hepatic artery thrombosis 030104 developmental biology medicine.anatomical_structure Neurological complications Etiology Central pontine myelinolysis business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Indian Journal of Transplantation, Vol 10, Iss 1, Pp 5-8 (2016) |
| ISSN: | 2212-0017 |
| Popis: | Aspirin used in the post-operative period as prophylaxis for hepatic artery thrombosis (HAT) increases the risk of neurological complications (NC) in adult living donor liver transplantation (LDLT) recipients was the hypothesis. Case control study was done on 1400 cases operated in our institute. Pediatric transplants, combined liver kidney, cadaver transplants, dual lobe transplants, preexisting organic neurological dysfunction and patients whose records were missing were excluded from the study. There were effectively 880 cases in non-aspirin group (NAG) and 440 cases in aspirin group (AG). The groups were matched for various factors. There were more alcoholics in AG and more ALFs in NAG. On subgroup analysis these two etiological factors were found to be statistically insignificant P > 0.05. So the prophylactic protocol was aspirin 75 mg once daily in all adults (age >12 years) once the platelet counts have reached 50,000 and there is no evidence of bleeding elsewhere. In pediatric population our protocol is use of aspirin 75 mg and clopidogrel 75 mg once daily once the platelet counts have reached 50,000 and there is no evidence of bleeding anywhere else. |
| Databáze: | OpenAIRE |
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