Endcaps for Stabilizing Short DNA Duplexes
| Autor: | Alan M. Friedman, Ganesan Balasundarum, Xiaolin Zu, Pei-Sze Ng, Maneesh Pingle, Donald E. Bergstrom |
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| Rok vydání: | 2003 |
| Předmět: |
Models
Molecular chemistry.chemical_classification Dna duplex Base Sequence Stereochemistry DNA General Medicine Nucleic Acid Denaturation Biochemistry chemistry.chemical_compound Terthiophene Drug Stability chemistry Covalent bond Amide Nucleic acid Genetics Nucleic Acid Conformation Thermodynamics Molecular Medicine Nucleotide Histone octamer |
| Zdroj: | Nucleosides, Nucleotides and Nucleic Acids. 22:1635-1637 |
| ISSN: | 1532-2335 1525-7770 |
| Popis: | The syntheses of endcaps for covalently linking the 3′ and 5′ hydroxyl groups of blunt end double-stranded DNA are described. Endcap diols were converted into DMTr protected phosphoramidites and incorporated between nucleotides 4 and 5 of a self-complementary octamer. The stabilizing effect of the endcaps on duplex DNA was determined by Tm experiments on the self-complementary octamer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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