Exploring whole-genome duplicate gene retention with complex genetic interaction analysis
| Autor: | Alan M. Moses, Elena Kuzmin, Michael Pryszlak, Anton Khmelinskii, Matej Usaj, Jolanda van Leeuwen, Alex N. Nguyen Ba, Michael Costanzo, Brenda J. Andrews, Michael Knop, Wen Wang, Oren Kraus, Charles Boone, Brenda Varriano, Elizabeth N. Koch, Benjamin VanderSluis, Chad L. Myers, Mojca Mattiazzi Usaj, Ming Che Hu, Amy Tresenrider |
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| Rok vydání: | 2019 |
| Předmět: |
Genome evolution
Saccharomyces cerevisiae Proteins Deletion mutant Gene regulatory network Computational biology Saccharomyces cerevisiae Biology Genome Article Evolution Molecular Peroxins 03 medical and health sciences Genes Duplicate Gene Duplication Gene duplication Gene Regulatory Networks Genetic Testing Protein Interaction Maps Gene 030304 developmental biology 0303 health sciences Multidisciplinary Genetic interaction 030302 biochemistry & molecular biology Membrane Proteins Genetic Techniques Human genome Genome Fungal Gene Deletion |
| Zdroj: | Science |
| ISSN: | 1095-9203 |
| Popis: | The fate of genes after duplication Gene duplication within an organism is a relatively common event during evolution. However, we cannot predict the fate of the duplicated genes: Will they be lost, evolve, or overlap in function within an organismal lineage or species? Kuzmin et al. explored the fate of duplicated gene function within the yeast Saccharomyces cerevisiae (see the Perspective by Ehrenreich). They examined how experimental deletions of one or two duplicated genes (paralogs) affected yeast fitness and were able to determine which genes have likely evolved new essential functions and which retained functional overlap, a condition the authors refer to as entanglement. On the basis of these results, they propose how entanglement affects the evolutionary trajectory of gene duplications. Science , this issue p. eaaz5667 ; see also p. 1424 |
| Databáze: | OpenAIRE |
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