Uterine Wnt/β-catenin signaling is required for implantation
| Autor: | Maud Jonnaert, Othman A. Mohamed, Cassandre Labelle-Dumais, Hugh J. Clarke, Kazuki Kuroda, Daniel Dufort |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Beta-catenin Uterus Mice Pregnancy Internal medicine medicine Animals Blastocyst Embryo Implantation Cytoskeleton Multidisciplinary biology Wnt signaling pathway Gene Expression Regulation Developmental Estrogens Biological Sciences Embryo Mammalian Epithelium Cell biology Wnt Proteins Endocrinology medicine.anatomical_structure biology.protein Intercellular Signaling Peptides and Proteins Female Signal transduction Developmental biology Signal Transduction |
| Popis: | Successful implantation relies on precisely orchestrated and reciprocal signaling between the implanting blastocyst and the receptive uterus. We have examined the role of the Wnt/β-catenin signaling pathway during the process of implantation and demonstrate that this pathway is activated during two distinct stages. Wnt/β-catenin signaling is first transiently activated in circular smooth muscle forming a banding pattern of activity within the uterus on early day 4. Subsequently, activation is restricted to the luminal epithelium at the prospective site of implantation. Activation at both sites requires the presence of the blastocyst. Furthermore, inhibition of Wnt/β-catenin signaling interferes with the process of implantation. Our results demonstrate that the Wnt/β-catenin signaling pathway plays a central role in coordinating uterus–embryo interactions required for implantation. |
| Databáze: | OpenAIRE |
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