Homocysteine and electroencephalographic rhythms in Alzheimer disease: A multicentric study
| Autor: | Roberta Ghidoni, Emanuele Cassetta, S. Bartesaghi, Raffaele Ferri, Guido Anello, Mariella Gurzì, C. Del Percio, Bartolo Lanuzza, Paolo Bosco, Rosanna Squitti, Giovanni B. Frisoni, G. Binetti, P.M. Rossini, Claudio Babiloni, Roberta Lizio, Mario Tombini, Luisa Benussi |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Alpha (ethology) Electroencephalography low resolution brain electromagnetic tomography Central nervous system disease chemistry.chemical_compound mild cognitive impairment Degenerative disease Alzheimer's disease electroencephalography homocysteine Aged Alzheimer Disease Biomarkers Brain Cognition Disorders Female Humans Neuroscience (all) Internal medicine medicine Dementia medicine.diagnostic_test General Neuroscience medicine.disease chemistry Cardiology Alpha-2 adrenergic receptor Psychology Neuroscience |
| Zdroj: | Neuroscience. 145:942-954 |
| ISSN: | 0306-4522 |
| Popis: | High plasma concentration of homocysteine is an independent risk factor for Alzheimer's disease (AD), due to microvascular impairment and consequent neural loss [Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346(7):476-483]. Is high plasma homocysteine level related to slow electroencephalographic (EEG) rhythms in awake resting AD subjects, as a reflection of known relationships between cortical neural loss and these rhythms? To test this hypothesis, we enrolled 34 mild AD patients and 34 subjects with mild cognitive impairment (MCI). Enrolled people were then subdivided into four sub-groups of 17 persons: MCI and AD subjects with low homocysteine level (MCI- and AD-, homocysteine level11 micromol/l); MCI and AD subjects with high homocysteine level (MCI+ and AD+, homocysteine levelor=11 micromol/l). Resting eyes-closed EEG data were recorded. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography (LORETA). Results showed that delta (frontal and temporal), theta (central, frontal, parietal, occipital, and temporal), alpha 1 (parietal, occipital, and temporal), and alpha 2 (parietal and occipital) sources were stronger in magnitude in AD+ than AD- group. Instead, no difference was found between MCI- and MCI+ groups. In conclusion, high plasma homocysteine level is related to unselective increment of cortical delta, theta, and alpha rhythms in mild AD, thus unveiling possible relationships among that level, microvascular concomitants of advanced neurodegenerative processes, and synchronization mechanisms generating EEG rhythms. |
| Databáze: | OpenAIRE |
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