Age-related changes in tissue macrophages precede cardiac functional impairment

Autor:	Anjana Chandran, Lina Wang, Alexei Ilinykh, James W. Godwin, Lucy Hersey, Alexander R. Pinto, Ryan J. Debuque, Nadia Rosenthal
Předmět:	Pathology Aging Geriatrics & Gerontology Cardiac fibrosis 0601 Biochemistry and Cell Biology Green fluorescent protein Mice Fibrosis Gene expression CX3CR1 HETEROGENEITY Oligonucleotide Array Sequence Analysis FRACTALKINE Microscopy Confocal Flow Cytometry Immunohistochemistry Cx3cr1 cardiac senescence HEART-FAILURE GROWTH Cardiac macrophages Life Sciences & Biomedicine Research Paper EXPRESSION tissue macrophages medicine.medical_specialty Heart Diseases Biology Real-Time Polymerase Chain Reaction DENDRITIC CELLS medicine Animals 1112 Oncology and Carcinogenesis Science & Technology RECEPTOR Macrophages MACROPINOCYTOSIS Cell Biology 0606 Physiology medicine.disease Molecular biology Mice Mutant Strains MODEL Mice Inbred C57BL inflammation ageing CCL24 Transcriptome Immunostaining
Zdroj:	Europe PubMed Central Aging (Albany NY) Scopus-Elsevier
Popis:	Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using theCx3cr1(GFP/+) mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1-GFP(hi) and Mrc1+GFP(hi) cTMs, are present in the young (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedf7373d666b1112d1658c83e5ecd7f http://europepmc.org/abstract/med/24861132 Zobrazit plný text záznamu