Enteric peripheral neuroblastoma in a calf
| Autor: | Saya Kagimoto, Masashi Sakurai, Miko Imaiumi, Yusuke Sakai, Masahiro Morimoto, Yuki Mitsui, Takeshi Okayama, Masato Hiyama, Kaori Haradono |
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| Rok vydání: | 2019 |
| Předmět: |
Doublecortin Domain Proteins
Pathology medicine.medical_specialty Enolase Cattle Diseases peripheral neuroblastoma Muscular layer Neuroblastoma doublecortin Biomarkers Tumor medicine Peripheral Neuroblastoma Animals General Veterinary biology business.industry Neuropeptides Nestin Note medicine.disease Immunohistochemistry digestive system diseases Staining Doublecortin medicine.anatomical_structure cattle Colonic Neoplasms biology.protein neuronal neoplasm Female Neoplasm Recurrence Local neuronal marker business Microtubule-Associated Proteins |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | An 11-month-old female Japanese Black calf had showed chronic intestinal symptoms. A large mass surrounding the colon wall that was continuous with the colon submucosa was surgically removed. After recurrence and euthanasia, a large mass in the colon region and metastatic masses in the omentum, liver, and lung were revealed at necropsy. Pleomorphic small cells proliferated in the mass and muscular layer of the colon. The cells were positively stained with anti-doublecortin (DCX), PGP9.5, nestin, and neuron specific enolase (NSE). Thus, the diagnosis of peripheral neuroblastoma was made. This is the first report of enteric peripheral neuroblastoma in animals. Also, clear DCX staining signal suggested usefulness of DCX immunohistochemistry to differentiate the neuroblastoma from other small cell tumors in cattle. |
| Databáze: | OpenAIRE |
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