Hypovitaminosis D in patients undergoing kidney transplant: the importance of sunlight exposure
| Autor: | Melani Ribeiro Custódio, Mariel J. Hernandez, Cristiane F Vilarta, Marianna D. Unger, Vanda Jorgetti, Elias David-Neto, Wagner V. Dominguez, Luciene M. dos Reis, Silvia M. Titan, Rosa M.A. Moysés |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Population Parathyroid hormone 030230 surgery Gastroenterology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Risk Factors Internal medicine Chronic Kidney Disease medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D education Kidney transplantation Aged Aged 80 and over Creatinine education.field_of_study lcsh:R5-920 business.industry Hypovitaminosis D General Medicine Environmental exposure Environmental Exposure Clinical Science Middle Aged medicine.disease Vitamin D Deficiency Kidney Transplantation Endocrinology chemistry Parathyroid Hormone Case-Control Studies Sunlight Female business lcsh:Medicine (General) Kidney disease |
| Zdroj: | Clinics, Volume: 72, Issue: 7, Pages: 415-421, Published: JUL 2017 Clinics Clinics, Vol 72, Iss 7, Pp 415-421 Clinics; v. 72 n. 7 (2017); 415-421 Clinics; Vol. 72 Núm. 7 (2017); 415-421 Clinics; Vol. 72 No. 7 (2017); 415-421 Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: Recent studies have shown a high prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D level less than 30 ng/ml, in both healthy populations and patients with chronic kidney disease. Patients undergoing kidney transplant are at an increased risk of skin cancer and are advised to avoid sunlight exposure. Therefore, these patients might share two major risk factors for hypovitaminosis D: chronic kidney disease and low sunlight exposure. This paper describes the prevalence and clinical characteristics of hypovitaminosis D among patients undergoing kidney transplant. METHODS: We evaluated 25-hydroxyvitamin D serum levels in a representative sample of patients undergoing kidney transplant. We sought to determine the prevalence of hypovitaminosis D, compare these patients with a control group, and identify factors associated with hypovitaminosis D (e.g., sunlight exposure and dietary habits). RESULTS: Hypovitaminosis D was found in 79% of patients undergoing kidney transplant, and the major associated factor was low sunlight exposure. These patients had higher creatinine and intact parathyroid hormone serum levels, with 25-hydroxyvitamin D being inversely correlated with intact parathyroid hormone serum levels. Compared with the control group, patients undergoing kidney transplant presented a higher prevalence of 25-hydroxyvitamin D deficiency and lower serum calcium, phosphate and albumin but higher creatinine and intact parathyroid hormone levels. CONCLUSIONS: Our results confirmed the high prevalence of hypovitaminosis D in patients undergoing kidney transplant. Therapeutic strategies such as moderate sunlight exposure and vitamin D supplementation should be seriously considered for this population. |
| Databáze: | OpenAIRE |
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