A Study of Acute and Chronic Tissue Changes in Surgical and Traumatically-Induced Experimental Models of Knee Joint Injury Using Magnetic Resonance Imaging and Micro-Computed Tomography
| Autor: | C. E. DeCamp, Keith D. Button, Ryan S. Fajardo, Hannah M. Pauly, Roger C. Haut, Kristine M. Fischenich, T.L. Haut Donahue |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Cartilage
Articular medicine.medical_specialty Anterior cruciate ligament Biomedical Engineering Osteoarthritis Knee Injuries Meniscus (anatomy) Knee Joint Menisci Tibial Article Bone and Bones 03 medical and health sciences 0302 clinical medicine Rheumatology medicine Animals Orthopedics and Sports Medicine Anterior Cruciate Ligament 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Micro computed tomography Cartilage Anterior Cruciate Ligament Injuries Magnetic resonance imaging 030229 sport sciences X-Ray Microtomography Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging Surgery Tibial Meniscus Injuries Dissection Disease Models Animal medicine.anatomical_structure Acute Disease Chronic Disease Disease Progression Rabbits business |
| Popis: | Summary Objective The objective of this study was to monitor the progression of joint damage in two animal models of knee joint trauma using two non-invasive, clinically available imaging modalities. Methods A 3-T clinical magnet and micro-computed tomography (μCT) was used to document changes immediately following injury (acute) and post-injury (chronic) at time points of 4, 8, or 12 weeks. Joint damage was recorded at dissection and compared to the chronic magnetic resonance imaging (MRI) record. Fifteen Flemish Giant rabbits were subjected to a single tibiofemoral compressive impact (ACLF), and 18 underwent a combination of anterior cruciate ligament (ACL) and meniscal transection (mACLT). Results All ACLF animals experienced ACL rupture, and 13 also experienced acute meniscal damage. All ACLF and mACLT animals showed meniscal and articular cartilage damages at dissection. Meniscal damage was documented as early as 4 weeks and worsened in 87% of the ACLF animals and 71% of the mACLT animals. Acute cartilage damage also developed further and increased in occurrence with time in both models. A progressive decrease in bone quantity and quality was documented in both models. The MRI data closely aligned with dissection notes suggesting this clinical tool may be a non-invasive method for documenting joint damage in lapine models of knee joint trauma. Conclusions The study investigates the acute to chronic progression of meniscal and cartilage damage at various time points, and chronic changes to the underlying bone in two models of posttraumatic osteoarthritis (PTOA), and highlights the dependency of the model on the location, type, and progression of damage over time. |
| Databáze: | OpenAIRE |
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