HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals
| Autor: | Janette Kwok, Cheuk-Kwong Lee, Mengbiao Guo, Jenny C. Y. Ho, Y.S. Chan, Derek Middleton, Wanling Yang, WH Tang, Godfrey Chi-Fung Chan, Liwei Lu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genotype Immunology Population 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Humans Immunology and Allergy Medicine Registries Allele education Allele frequency Genotyping Genetics education.field_of_study HLA-A Antigens business.industry Histocompatibility Testing Haplotype Hematopoietic Stem Cell Transplantation General Medicine Fetal Blood HLA-A Transplantation Genetics Population 030104 developmental biology Haplotypes HLA-B Antigens Blood Banks Hong Kong business HLA-DRB1 Chains 030215 immunology |
| Zdroj: | Human Immunology. 77:1111-1112 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2016.10.005 |
| Popis: | HLA-A, -B, -C and -DRB1 gene and haplotype frequencies have been calculated from 7595 southern Chinese unrelated donors in a Hong Kong Bone Marrow Donor Registry. This is the first large-scale paper to report the distribution of A-C-B-DRB1 alleles in Hong Kong Chinese. This information is important for phylogenetic, comparative studies and estimating the optimal and cost-effective donor size and likelihood of obtaining appropriately matched donors for Chinese patients awaiting haematopoietic stem cell transplantation. The allele and haplotype data are available in the Allele Frequencies Net Database under the population name ''Hong Kong Chinese BMDR'' and the identifier (AFND003357). |
| Databáze: | OpenAIRE |
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