Effects of intravenous emulsified perfluorochemicals on hepatic cytochrome P-450
| Autor: | Henry A. Sloviter, Rong Huang, David Y. Cooper |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Cytochrome Perfluorotributylamine Pharmacology Biochemistry chemistry.chemical_compound Cytochrome P-450 Enzyme System Blood Substitutes medicine Animals Demethylation Fluorocarbons biology Hepatic cytochrome Benzphetamine Organ Size Rats Perfluorodecalin Liver chemistry Phenobarbital Injections Intravenous Microsomes Liver biology.protein Emulsions medicine.drug |
| Zdroj: | Biochemical Pharmacology. 36:4331-4334 |
| ISSN: | 0006-2952 |
| Popis: | Intravenous infusion of emulsified perfluorodecalin in rats caused a large increase in hepatic cytochrome P-450 concentration which persisted for many weeks. In contrast, hepatic cytochrome P-450 concentration was not changed significantly after infusion of perfluorotributylamine, but subsequent administration of phenobarbital caused the usual increase of cytochrome P-450. The cytochrome P-450 activity for demethylation of benzphetamine was decreased slightly after perfluorodecalin but was unchanged after perfluorotributylamine. The difference in the effects of these perfluorochemicals on hepatic cytochrome P-450 may be related to the difference in the time these compounds are retained in the liver. |
| Databáze: | OpenAIRE |
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