The effect of plastic bottled water consumption on outcomes of ICSI cycles undertaken for unexplained infertility
| Autor: | Oya Aldemir, Ozlem Moraloglu Tekin, Funda Gucel, Berna Dilbaz, Iskender Kaplanoglu, Serdar Dilbaz, Nefise Nazlı Yenigul, Runa Ozelci, Emre Baser |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Intracytoplasmic sperm injection Dietary Exposure Phenols Pregnancy medicine Humans Estrogens Non-Steroidal Prospective Studies Sperm Injections Intracytoplasmic Benzhydryl Compounds Prospective cohort study Unexplained infertility urogenital system Obstetrics business.industry Drinking Water Obstetrics and Gynecology Bottled water Follicular fluid Embryo transfer Follicular Fluid Reproductive Medicine Maternal Exposure Female Live birth business Embryo quality Developmental Biology |
| Zdroj: | Reproductive BioMedicine Online. 43:91-99 |
| ISSN: | 1472-6483 |
| DOI: | 10.1016/j.rbmo.2021.04.010 |
| Popis: | Do bisphenol A (BPA) levels in maternal urine, serum and follicular fluid affect embryo quality and intracytoplasmic sperm hinjection (ICSI) cycle outcomes in women with unexplained infertility?Prospective study conducted between 1 April 2019 and 30 September 2019. The study cohort consisted of 82 women aged between 23 and 33 years who underwent intracytoplasmic sperm injection owing to unexplained infertility and provided urine, blood and follicular fluid samples on the day of oocyte retrieval. Consumption of drinking water from plastic carboys or bottles at home were considered as chronic BPA exposure. Demographic features and IVF outcomes of the patients were collected.Among the 82 women with unexplained infertility, clinical pregnancy was achieved in 22 (26.8%) patients after the IVF and embryo transfer cycle. The patients who consumed tap water had statistically significantly lower BPA values in three body fluids compared with patients who consumed plastic bottled water (all P0.001). Women who had grade 1 embryos transferred had lower serum BPA values than women who had grade 2 embryos transferred (10.8 ± 5.2 versus 26.9 ± 22 ng/ml, P = 0.003). Serum and follicular fluid BPA levels were statistically significantly higher in women who failed to achieve clinical pregnancy (P0.001, P = 0.006, respectively) and obtain a live birth (both P = 0.007).A negative relationship was found between serum and follicular fluid BPA levels and embryo quality, clinical pregnancy and live birth in these women. In addition, the BPA levels of women who consume tap water at home were lower than those who use plastic bottled water. |
| Databáze: | OpenAIRE |
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