Iron and ADHD. Time to Move Beyond Serum Ferritin Levels
| Autor: | Renato Donfrancesco, Samuele Cortese, Vittorio Sargentini, Pasquale Parisi, Francesca Martines, Nicola Vanacore |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty adhd ferritin iron therapy Intelligence behavioral disciplines and activities Gastroenterology Severity of Illness Index Internal medicine mental disorders Severity of illness Evaluation methods Developmental and Educational Psychology medicine Attention deficit hyperactivity disorder Humans Statistical analysis Adhd symptoms Child Serum ferritin Intelligence quotient biology medicine.disease Ferritin Clinical Psychology Attention Deficit Disorder with Hyperactivity Ferritins biology.protein Central Nervous System Stimulants Female Psychology Clinical psychology |
| Popis: | Objective: (a) To compare serum ferritin levels in a sample of stimulant-naïve children with ADHD and matched controls and (b) to assess the association of serum ferritin to ADHD symptoms severity, ADHD subtypes, and IQ. Method: The ADHD and the control groups included 101 and 93 children, respectively. Serum ferritin levels were determined with the enzyme-linked immunosorbent assay method. Results: Serum ferritin did not significantly differ between children with ADHD and controls, as well as among ADHD subtypes. Correlations between serum ferritin levels and measures related to IQ or ADHD severity were not significant. Conclusion: This is the largest controlled study that assessed ferritin levels in stimulant-naïve ADHD children. The findings of this study do not support a significant relationship between serum ferritin levels and ADHD. However, the authors’ results based on peripheral measures of iron do not rule out a possible implication of brain iron deficiency in ADHD, grounded on neurobiological hypotheses and preliminary empirical evidence. |
| Databáze: | OpenAIRE |
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