LATE-OCCURRING PULMONARY PATHOLOGIES FOLLOWING INHALATION OF MIXED OXIDE (URANIUM + PLUTONIUM OXIDE) AEROSOL IN THE RAT
| Autor: | J. L. Poncy, M.-C. Abram, N. M. Griffiths, P. Fritsch, A. Van der Meeren, J.-F. Bernaudin |
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| Rok vydání: | 2010 |
| Předmět: |
Liver Cirrhosis
Male Pathology medicine.medical_specialty Lung Neoplasms Time Factors Epidemiology Health Toxicology and Mutagenesis chemistry.chemical_element Rats Sprague-Dawley Fibrosis Administration Inhalation medicine Animals Radiology Nuclear Medicine and imaging Lung cancer Lung MOX fuel Aerosols Inhalation Radiochemistry Cancer Dose-Response Relationship Radiation medicine.disease Immunohistochemistry Uranium Compounds Plutonium Rats Dose–response relationship medicine.anatomical_structure chemistry Body Burden |
| Zdroj: | Health Physics. 99:347-356 |
| ISSN: | 0017-9078 |
| DOI: | 10.1097/hp.0b013e3181c75750 |
| Popis: | Accidental exposure by inhalation to alpha-emitting particles from mixed oxide (MOX: uranium and plutonium oxide) fuels is a potential long-term health risk to workers in nuclear fuel fabrication plants. For MOX fuels, the risk of lung cancer development may be different from that assigned to individual components (plutonium, uranium) given different physico-chemical characteristics. The objective of this study was to investigate late effects in rat lungs following inhalation of MOX aerosols of similar particle size containing 2.5 or 7.1% plutonium. Conscious rats were exposed to MOX aerosols and kept for their entire lifespan. Different initial lung burdens (ILBs) were obtained using different amounts of MOX. Lung total alpha activity was determined by external counting and at autopsy for total lung dose calculation. Fixed lung tissue was used for anatomopathological, autoradiographical, and immunohistochemical analyses. Inhalation of MOX at ILBs ranging from 1-20 kBq resulted in lung pathologies (90% of rats) including fibrosis (70%) and malignant lung tumors (45%). High ILBs (4-20 kBq) resulted in reduced survival time (N = 102; p < 0.05) frequently associated with lung fibrosis. Malignant tumor incidence increased linearly with dose (up to 60 Gy) with a risk of 1-1.6% Gy for MOX, similar to results for industrial plutonium oxide alone (1.9% Gy). Staining with antibodies against Surfactant Protein-C, Thyroid Transcription Factor-1, or Oct-4 showed differential labeling of tumor types. In conclusion, late effects following MOX inhalation result in similar risk for development of lung tumors as compared with industrial plutonium oxide. |
| Databáze: | OpenAIRE |
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