Cognitive changes during the menopausal transition: a longitudinal study in women with and without HIV
| Autor: | Kathryn Anastos, Drenna Waldrop, Gayle Springer, Adaora A. Adimora, Leah H. Rubin, David E. Vance, Deborah Gustafson, Derek M. Dykxhoorn, Seble Kassaye, Joel Milam, Kathleen M. Weber, Pauline M. Maki |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Longitudinal study 030209 endocrinology & metabolism HIV Infections Verbal learning Odds 03 medical and health sciences 0302 clinical medicine Cognition medicine Verbal fluency test Humans Effects of sleep deprivation on cognitive performance Longitudinal Studies 030219 obstetrics & reproductive medicine business.industry Working memory Obstetrics and Gynecology medicine.disease Perimenopause Menopause Female business Demography |
| Zdroj: | Menopause (New York, N.Y.). 28(4) |
| ISSN: | 1530-0374 |
| Popis: | OBJECTIVE To assess longitudinal changes in cognitive performance across menopause stages in a sample comprised primarily of low-income women of color, including women with HIV (WWH). METHODS A total of 443 women (291 WWH; 69% African American; 18% Hispanic; median age = 42 y) from the Women's Interagency HIV Study completed tests of verbal learning and memory, attention/working memory, processing speed, verbal fluency, motor skills, and executive function first at an index premenopausal visit and thereafter once every 2 years for up to six visits (mean follow-up = 5.7 y). General linear-mixed effects regression models were run to estimate associations between menopause stages and cognition, in the overall sample and in WWH. We examined both continuous scores and categorical scores of cognitive impairment (yes/no >1 standard deviation below the mean). RESULTS Adjusting for age and relevant covariates, the overall sample and WWH showed longitudinal declines in continuous measures of learning, memory, and attention/working memory domains from the premenopause to the early perimenopause and from the premenopause to the postmenopause, Ps |
| Databáze: | OpenAIRE |
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