Anterior cruciate ligament reconstruction using a composite collagenous prosthesis
| Autor: | Y. P. Kato, Michael G. Dunn, Joseph P. Zawadsky, Frederick H. Silver, J R Bechler, R S Ochner, Alfred J. Tria |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Ultimate load Time Factors Anterior cruciate ligament reconstruction medicine.medical_treatment Anterior cruciate ligament Composite number Physical Therapy Sports Therapy and Rehabilitation Matrix (biology) Prosthesis Design Prosthesis 03 medical and health sciences 0302 clinical medicine Tensile Strength Ultimate tensile strength medicine Animals Orthopedics and Sports Medicine Anterior Cruciate Ligament Bioprosthesis 030222 orthopedics business.industry 030229 sport sciences Anatomy Biomechanical Phenomena medicine.anatomical_structure Collagen Rabbits business Type I collagen |
| Zdroj: | The American Journal of Sports Medicine. 20:507-515 |
| ISSN: | 1552-3365 0363-5465 |
| DOI: | 10.1177/036354659202000504 |
| Popis: | We evaluated a prototype composite collagenous an terior cruciate ligament replacement device designed to possess the advantages of biological grafts and syn thetic materials. Collagenous anterior cruciate ligament prostheses were made by embedding 225 reconsti tuted type I collagen fibers in a type I collagen matrix, and placing polymethylmethacrylate bone fixation plugs on the ends. The collagenous prosthesis was used to replace the anterior cruciate ligament of 31 mature rabbits. At 4 and 20 weeks postimplantation, histologic and mechanical studies were performed on the devel oping neoligament tissue, and compared to values for the contralateral sham-operated control. At 4 weeks, neoligament tissue infiltrated the collagen fibers of the prostheses. The tibial bone tunnel attach ment site contained new bone approaching the fibrous neoligament. The glutaraldehyde-treated prosthetic fi bers appeared intact, while the carbodiimide-treated prosthetic fibers began to resorb. The ultimate load and ultimate tensile strength of femur-neoligament-tibia complexes had decreased. At 20 weeks, glutaraldehyde-treated fibers appeared partially intact; in contrast, the carbodiimide-treated prostheses appeared to be completely degraded, and were replaced by organized, crimped neoligament tis sue. The ultimate tensile strength and ultimate load increased substantially due to deposition and remod eling of neoligament tissue. The neoligament ultimate load was 2 to 4 times the initial load value of the prosthesis. Implantation of a resorbable, composite collagenous anterior cruciate ligament prosthesis encourages the development of functional neoligament tissue. Studies are underway to optimize the mechanical and biological properties of the prostheses. |
| Databáze: | OpenAIRE |
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