Loop Electrosurgical Excision Procedure Combined With Cold Coagulation for Cervical Intraepithelial Neoplasia and Adenocarcinoma In-Situ: A Feasible Treatment With a Low Risk of Residual/Recurrent Disease
| Autor: | Sun Joo Lee, Nae Ry Kim, Ji Yeon Choi, Wook Youn Kim, Eun Jung Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty Resection margin genetic structures Epidemiology medicine.medical_treatment Urology Cervical intraepithelial neoplasia Loop electrosurgical excision procedure lcsh:RC254-282 lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Recurrent disease Medicine lcsh:RC109-216 neoplasms 030219 obstetrics & reproductive medicine Hysterectomy business.industry Cold coagulation Microinvasive carcinoma medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens female genital diseases and pregnancy complications Infectious Diseases Oncology 030220 oncology & carcinogenesis Adenocarcinoma Histopathology business Microinvasive Squamous Cell Carcinoma Research Article |
| Zdroj: | Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-6 (2020) Infectious Agents and Cancer |
| DOI: | 10.21203/rs.3.rs-51039/v1 |
| Popis: | Objective This study was performed to evaluate the significance of positive resection margins (RMs) with the loop electrosurgical excision procedure combined with cold coagulation (LEEP with CC) as a definitive treatment for patients with cervical intraepithelial neoplasia (CIN) and adenocarcinoma in-situ. Methods We retrospectively reviewed 467 patients who underwent LEEP with CC. A right-angled triangular loop in a single pass followed by a CC (120 °C) to the cone bed for 10 to 20 s was used. Pathology reports and clinical data were obtained and evaluated. Results Histopathology evaluation of LEEP tissue samples revealed the presence of CIN 1 in 69, CIN 2/3 in 366, AIS in 5 and invasive carcinoma in 16 (microinvasive squamous cell carcinoma (SCC) and invasive SCC, 13 and 3) patients. Margins were positive in 66 (14.5%) cases: 0 in CIN 1, 54 in CIN 2/3 (12.4%), 1 in AIS (20.0%) and 11 in microinvasive/invasive SCC (68.8%). Although 54 CIN2/3 patients with positive RMs did not undergo additional treatment, 1 of these (1.9%) was confirmed to have residual CIN3 at the first follow-up. Two of 8 (25.0%) microinvasive SCC patients with positive RMs were confirmed to have residual diseases (1 microinvasive SCC and 1 invasive SCC) after hysterectomy. Four out of 360 (1 positive RM, 3 negative RM) CIN cases recurred during the study period. Conclusions These results suggest that CIN patients with positive RMs after LEEP with CC may be followed up without additional treatment. |
| Databáze: | OpenAIRE |
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