Task‐related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults
| Autor: | Patrick Smith, Donald D. Glower, Kathleen A. Welsh-Bohmer, Todd B. Harshbarger, John H. Alexander, Jeffrey N. Browndyke, Viral Panchal, Zachary A. Monge, Joseph P. Mathew, Roberto Cabeza, Miles Berger, Mark F. Newman, Tiffany L. Bisanar |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Gyrus Cinguli Article 03 medical and health sciences Postoperative Complications 0302 clinical medicine 030202 anesthesiology Functional neuroimaging Internal medicine medicine Humans Cognitive Dysfunction Radiology Nuclear Medicine and imaging Cardiac Surgical Procedures Cognitive decline Psychiatry Aged Aged 80 and over Radiological and Ultrasound Technology Working memory Cognition Perioperative Middle Aged Cardiac surgery Memory Short-Term Neurology Cardiothoracic surgery Posterior cingulate Cardiology Female Neurology (clinical) Anatomy Psychology 030217 neurology & neurosurgery |
| Zdroj: | Human Brain Mapping. 39:985-1003 |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.23898 |
| Popis: | Objectives Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and nonsurgical controls. Experimental design Older cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals. We measured postoperative changes in degree centrality, the number of edges attached to a brain node, and local coherence, the temporal homogeneity of regional functional correlations, using voxel-wise graph theory-based FC metrics. Group × time differences were evaluated in these FC metrics associated with increased N-back working memory load (2-back > 1-back), using a two-stage partitioned variance, mixed ANCOVA. Principal observations Cardiac surgery patients demonstrated postoperative working memory load-related degree centrality increases in the left dorsal posterior cingulate cortex (dPCC; p |
| Databáze: | OpenAIRE |
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