Synthesis and characterization of new Cr(III), Fe(III) and Cu(II) complexes incorporating multi-substituted aryl imidazole ligand: Structural, DFT, DNA binding, and biological implications

Autor: Mohamed R. Shehata, Ayman Nafady, Mohamed A. Bakheet, Antar A. Abdelhamid, Laila H. Abdel-Rahman, Adel A. Marzouk, Ahmed M. Abu-Dief, Omar A. Almaghrabi
Rok vydání: 2019
Předmět:
Chromium
Models
Molecular
Spectrophotometry
Infrared
Proton Magnetic Resonance Spectroscopy
02 engineering and technology
Ligands
01 natural sciences
Medicinal chemistry
Analytical Chemistry
chemistry.chemical_compound
Anti-Infective Agents
Coordination Complexes
Instrumentation
Spectroscopy
Density Functional Theory
Chemistry
Viscosity
Imidazoles
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Atomic and Molecular Physics
and Optics
visual_art
Thermogravimetry
visual_art.visual_art_medium
Thermodynamics
0210 nano-technology
Thermogravimetric analysis
Iron
chemistry.chemical_element
Antineoplastic Agents
Microbial Sensitivity Tests
010402 general chemistry
Metal
Inhibitory Concentration 50
Cell Line
Tumor
Humans
Carbon-13 Magnetic Resonance Spectroscopy
Bacteria
Aryl
Magnetic Phenomena
Electric Conductivity
Fungi
DNA
Carbon-13 NMR
Electrophoreses
Magnetic susceptibility
0104 chemical sciences
Kinetics
Stoichiometry
Copper
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 228
ISSN: 1873-3557
Popis: Designing new metal-based molecular antibiotics is an efficient approach to overcome the growing threat of antimicrobial resistance. In this paper, novel Cr(III), Fe(III) and Cu(II) complexes comprising substituted aryl imidazole ligand (MSEB), namely (2-(1-(2-hydroxyethyl)-4,5-diphenyl-1H-imidazole-2-yl)(4-bromophenol)) have been synthesized and characterized using infra-red (IR), ultraviolet-visible (UV-Vis) and 1H, 13C NMR spectroscopic techniques, together with elemental (CHN) and thermogravimetric analyses, molar conductance, and magnetic susceptibility measurements. The combined results along with the DFT calculations revealed a 1:1 (M: L) stoichiometric ratio and the complexes adopted distorted-octahedral geometries to afford [Cr(MSEB)Cl2(H2O)2], [Fe(MSEB)(NO3)2(H2O)2] and [Cu(MSEB)Cl(H2O)3] respectively. Biological studies showed that all complexes exhibited powerful antimicrobial activity against various strains of bacteria and fungi, S. aureus (+ve), E. coli (-ve) and P. aeruginosa (-ve) bacteria and T. Rubrum, C. albicans, and A. flavus fungi. Moreover, the three metal-complexes showed high in vitro cytotoxicity against Colon (HCT-116), Breast (MCF-7), and hepatic cellular (HepG-2) carcinoma cell lines, with MSEBCu complex being the most cytotoxic one. Finally the binding interactions of the complexes with CT-DNA were explored using UV-Vis spectroscopy, viscosity and gel electrophoreses measurements.
Databáze: OpenAIRE
Externí odkaz: