COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure
Autor: | Tuula Stjernvall, Torben Steiniche, Håkan Wallin, Michael Dictor, Kirsti Husgafvel-Pursiainen, Henrik Wolff, Reetta Holmila, Diane Cyr, Danièle Luce, Pirjo Heikkilä, Jette Bornholdt |
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Přispěvatelé: | Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Forensic Psychiatry, University of Gothenburg (GU), Vejle hospital, University of Southern Denmark (SDU), National Research Centre for the Working Environment, National Research Centre for the Working Environment (NRCWE), Helsinki University Central Hospital, Kaniewski, Nadine, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
Rok vydání: | 2008 |
Předmět: |
Cancer Research
medicine.medical_specialty Pathology Tumor suppressor gene Nose Neoplasms Adenocarcinoma Biology medicine.disease_cause Nose neoplasm Article Gene Expression Regulation Enzymologic 03 medical and health sciences 0302 clinical medicine Occupational Exposure Biomarkers Tumor medicine Humans 030304 developmental biology 0303 health sciences Cancer Dust Histology medicine.disease Immunohistochemistry Wood 3. Good health Gene Expression Regulation Neoplastic Oncology [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Cyclooxygenase 2 Tumor Markers Biological 030220 oncology & carcinogenesis Carcinoma Squamous Cell [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Histopathology Tumor Suppressor Protein p53 Carcinogenesis Paranasal Sinus Neoplasms |
Zdroj: | Holmila, R, Cyr, D, Luce, D, Heikkilä, P, Dictor, M, Steiniche, T, Stjernvall, T, Bornholdt, J, Wallin, H, Wolff, H & Husgafvel-Pursiainen, K 2008, ' COX-2 and p53 in human sinonasal cancer : COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure ', International Journal of Cancer, vol. 122, no. 9, pp. 2154-2159 . https://doi.org/10.1002/ijc.23360 International Journal of Cancer International Journal of Cancer, Wiley, 2008, 122 (9), pp.2154-2159. ⟨10.1002/ijc.23360⟩ International Journal of Cancer, 2008, 122 (9), pp.2154-2159. ⟨10.1002/ijc.23360⟩ |
ISSN: | 0020-7136 1097-0215 |
Popis: | International audience; The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of cancer. Many signals that activate COX-2 also induce tumor suppressor p53, a transcription factor central in cellular stress response. We investigated COX-2 and p53 expressions by immunohistochemistry in 50 SNCs (23 adenocarcinomas, and 27 squamous cell carcinomas (SCC); 48 analyzed for COX-2; 41 for p53). Occupational histories and smoking habits were available for majority of the cases. Most of the adenocarcinoma cases with exposure history data had been exposed to wood dust at work in the past (88%, 14/16). For smokers, 63% (12/19) presented with SSC, whereas 64% (7/11) of nonsmokers displayed adenocarcinoma. COX-2 was expressed at higher levels in adenocarcinoma as compared to SSC (p < 0.001). COX-2 expression showed significant association with occupational exposure to wood dust (p = 0.024), and with nonsmoking status (p = 0.001). No statistically significant associations between the exposures and p53 accumulation were found; however, the p53 accumulation pattern (p = 0.062 for wood dust exposure) resembled that of COX-2 expression. In summary, our findings show increased COX-2 expression in SNC adenocarcinoma with wood dust exposure, suggesting a role for inflammatory components in the carcinogenesis process. In contrast, SCCs predominated among smokers and expressed COX-2 rarely; this may suggest at least partially different molecular mechanisms. (c) 2008 Wiley-Liss, Inc. |
Databáze: | OpenAIRE |
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