COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure

Autor: Tuula Stjernvall, Torben Steiniche, Håkan Wallin, Michael Dictor, Kirsti Husgafvel-Pursiainen, Henrik Wolff, Reetta Holmila, Diane Cyr, Danièle Luce, Pirjo Heikkilä, Jette Bornholdt
Přispěvatelé: Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Forensic Psychiatry, University of Gothenburg (GU), Vejle hospital, University of Southern Denmark (SDU), National Research Centre for the Working Environment, National Research Centre for the Working Environment (NRCWE), Helsinki University Central Hospital, Kaniewski, Nadine, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2008
Předmět:
Cancer Research
medicine.medical_specialty
Pathology
Tumor suppressor gene
Nose Neoplasms
Adenocarcinoma
Biology
medicine.disease_cause
Nose neoplasm
Article
Gene Expression Regulation
Enzymologic
03 medical and health sciences
0302 clinical medicine
Occupational Exposure
Biomarkers
Tumor
medicine
Humans
030304 developmental biology
0303 health sciences
Cancer
Dust
Histology
medicine.disease
Immunohistochemistry
Wood
3. Good health
Gene Expression Regulation
Neoplastic
Oncology
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Cyclooxygenase 2
Tumor Markers
Biological
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Histopathology
Tumor Suppressor Protein p53
Carcinogenesis
Paranasal Sinus Neoplasms
Zdroj: Holmila, R, Cyr, D, Luce, D, Heikkilä, P, Dictor, M, Steiniche, T, Stjernvall, T, Bornholdt, J, Wallin, H, Wolff, H & Husgafvel-Pursiainen, K 2008, ' COX-2 and p53 in human sinonasal cancer : COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure ', International Journal of Cancer, vol. 122, no. 9, pp. 2154-2159 . https://doi.org/10.1002/ijc.23360
International Journal of Cancer
International Journal of Cancer, Wiley, 2008, 122 (9), pp.2154-2159. ⟨10.1002/ijc.23360⟩
International Journal of Cancer, 2008, 122 (9), pp.2154-2159. ⟨10.1002/ijc.23360⟩
ISSN: 0020-7136
1097-0215
Popis: International audience; The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of cancer. Many signals that activate COX-2 also induce tumor suppressor p53, a transcription factor central in cellular stress response. We investigated COX-2 and p53 expressions by immunohistochemistry in 50 SNCs (23 adenocarcinomas, and 27 squamous cell carcinomas (SCC); 48 analyzed for COX-2; 41 for p53). Occupational histories and smoking habits were available for majority of the cases. Most of the adenocarcinoma cases with exposure history data had been exposed to wood dust at work in the past (88%, 14/16). For smokers, 63% (12/19) presented with SSC, whereas 64% (7/11) of nonsmokers displayed adenocarcinoma. COX-2 was expressed at higher levels in adenocarcinoma as compared to SSC (p < 0.001). COX-2 expression showed significant association with occupational exposure to wood dust (p = 0.024), and with nonsmoking status (p = 0.001). No statistically significant associations between the exposures and p53 accumulation were found; however, the p53 accumulation pattern (p = 0.062 for wood dust exposure) resembled that of COX-2 expression. In summary, our findings show increased COX-2 expression in SNC adenocarcinoma with wood dust exposure, suggesting a role for inflammatory components in the carcinogenesis process. In contrast, SCCs predominated among smokers and expressed COX-2 rarely; this may suggest at least partially different molecular mechanisms. (c) 2008 Wiley-Liss, Inc.
Databáze: OpenAIRE
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