Prognostic and predictive factors for Taiwanese patients with advanced biliary tract cancer undergoing frontline chemotherapy with gemcitabine and cisplatin: a real-world experience
| Autor: | Wen-Chi Chou, Chia-Hsun Hsieh, Chiao-En Wu, Cheng-Yu Lin, John Wen-Cheng Chang, Chun-Nan Yeh, Jen-Shi Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Taiwan Percutaneous transhepatic cholangiography lcsh:RC254-282 Deoxycytidine Surgical oncology Internal medicine Antineoplastic Combined Chemotherapy Protocols Genetics medicine Chemotherapy Humans Neutrophil to lymphocyte ratio Aged Retrospective Studies Cisplatin Prognostic factor business.industry Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis Gemcitabine Survival Rate Regimen Biliary Tract Neoplasms Cohort Biliary tract cancer Female business medicine.drug Research Article Follow-Up Studies |
| Zdroj: | BMC Cancer BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020) |
| ISSN: | 1471-2407 |
| Popis: | Background Chemotherapy with gemcitabine and cisplatin has been the standard of care in first-line chemotherapy for advanced biliary tract cancer (BTC) since the trial ABC-02 was published in 2010. We aimed to investigate the prognostic and predictive factors of this regimen in a cohort of Taiwanese patients with advanced BTC. Methods A total of 118 patients with histologically confirmed BTC treated at Chang Gung Memorial Hospital at Linkou from 2012 to 2017 were retrospectively reviewed. Results The median progression-free survival (PFS) and overall survival (OS) were 3.6 months and 8.4 months, respectively. In the multivariate analysis, neutrophil to lymphocyte ratio (NLR) > 7.45, biliary drainage requiring both percutaneous transhepatic cholangiography drainage (PTCD) and internal stenting, and tumor responses with progressive diseases and not assessed were independent poor prognostic factors for PFS. Male sex, NLR > 7.45, alkaline phosphatase> 94 U/L, biliary drainage requiring both PTCD and internal stenting, and tumor responses with stable disease, progressive diseases and not assessed were independent poor prognostic factors for OS. Monocyte to lymphocyte ratio (MLR) ≤ 0.28 was the only significant predictive factor for the tumor response. Patients with complete response/partial response had significantly lower MLR than patients with other tumor responses. Conclusion We identified three important prognostic factors, namely tumor response, NLR, and biliary drainage requiring both PTCD and internal stenting for both PFS and OS. MLR was the only significant predictive factor for the tumor response. These findings could provide physicians with more information to justify the clinical outcomes in patients with advanced BTC in real-world practice. |
| Databáze: | OpenAIRE |
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