Decreased striatal D2 dopamine receptor mRNA synthesis during aging
| Autor: | Sara G. Carlson, George S. Roth, Eugene R. Mesco, James A. Joseph |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Aging Down-Regulation Nerve Tissue Proteins Striatum Biology Receptors Dopamine Cellular and Molecular Neuroscience Dopamine receptor D1 Dopamine Internal medicine Dopamine receptor D2 Basal ganglia medicine Animals RNA Messenger Rats Wistar Receptor Molecular Biology DNA Corpus Striatum Rats Endocrinology Dopamine receptor Catecholamine medicine.drug |
| Zdroj: | Brain research. Molecular brain research. 17(1-2) |
| ISSN: | 0169-328X |
| Popis: | Decreases in striatal dopamine receptors during aging are related to deficits in motor functions, and are highly correlated with the D2 receptor subtype. Some receptor loss is attributed to cell death, while the remainder is thought to be related to synthetic capacity. We discuss here our findings, for isolated rat striatal nuclei, which indicate a 50% overall decrease in the synthesis of the dopamine D2 mRNA in aged nuclei. |
| Databáze: | OpenAIRE |
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