Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats
| Autor: | Luis Granero, Lucía Hipólito, M. J. Cano-Cebrián, Ana Polache, Sandra Fernández-Rodríguez, Teodoro Zornoza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Drug Alcohol Drinking Injections Subcutaneous media_common.quotation_subject Drug Evaluation Preclinical Alcohol Pharmacology Infusions Subcutaneous CIENCIAS DE LA VIDA [UNESCO] ethanol relapse prevention Acetylcysteine Random Allocation 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Subcutaneous injection 0302 clinical medicine Pharmacotherapy alcohol use disorders Recurrence glutamate neurotransmission UNESCO::CIENCIAS DE LA VIDA Animals Medicine Rats Wistar media_common Ethanol business.industry Abstinence alcohol deprivation effec Rats Substance Withdrawal Syndrome Alcoholism Regimen 030104 developmental biology chemistry Models Animal business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cano-Cebrián MJ, Fernández-Rodríguez S, Hipólito L, Granero L, Polache A, Zornoza T. Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats. J Neurosci Res. 2021 Feb;99(2):638-648. RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| Popis: | Alcohol use disorders are chronic and highly relapsing disorders, thus alcoholic patients have a high rate of recidivism for drug use even after long periods of abstinence. The literature points to the potential usefulness of N-acetylcysteine (NAC) in the management of several substance use disorders probably due to its capacity to restore brain homeostasis of the glutamate system disrupted in addiction. However, there is little evidence in the case of alcohol. The aim of this study was to explore the potential anti-relapse efficacy of NAC using the alcohol deprivation effect (ADE) model in long-term experienced rats. Two experiments were performed in male Wistar rats to: (a) test the efficacy of NAC to prevent relapse and (b) discriminate the best administration schedule (intermittent vs. continuous) for NAC. In the first experiment, animals were implanted with mini-osmotic pumps delivering 0 or 1 mg/hr NAC during 14 days. In a second experiment, rats received 0, 60, or 100 mg/kg once daily by subcutaneous injection. The efficacy to prevent ADE was evaluated in both experiments. NAC subcutaneously administered, either by continuous infusion or by intermittent injections regimen, is able to block the ADE. The best results were obtained after using 60 mg/kg NAC dose. Our findings support the hypothesis that NAC may represent a valuable therapy in the management of alcohol relapse. GVA2016-096 |
| Databáze: | OpenAIRE |
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