Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications
Autor: | Baki Hazer, Ebru Kilicay, Elif Ilhan, Zeynep Karahaliloğlu, Emir Baki Denkbaş |
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Přispěvatelé: | Kapadokya Üniversitesi, Sabire Yazıcı Fen Edebiyat Fakültesi, Zonguldak Bülent Ecevit Üniversitesi |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
food.ingredient
medicine.drug_class Antibiotics soybean oil Pre-osteoblastic MCT3T3-E1 Cells 02 engineering and technology polystyrene 010402 general chemistry Bone tissue 01 natural sciences Soybean oil Silver nanoparticle Microbiology chemistry.chemical_compound food medicine General Materials Science High prevalence biology Mechanical Engineering technology industry and agriculture silver nanoparticle equipment and supplies 021001 nanoscience & nanotechnology Condensed Matter Physics Bone cement biology.organism_classification 0104 chemical sciences medicine.anatomical_structure chemistry Mechanics of Materials Polystyrene 0210 nano-technology Bacteria |
Popis: | *Karahaliloğlu, Zeynep ( Aksaray, Yazar ) Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (βTCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity of the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 β-TCP) w/w in β-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects. |
Databáze: | OpenAIRE |
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