DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis
| Autor: | Nathalie Janel, Antonin Lamaziere, Chrystèle Racine, François Vialard, Rodolphe Dard, Valérie Serazin, Nadim Kassis, Estelle Parizot, Farah Ghieh, Nathalie di Clemente, Manon Moreau, Leslie Brehier |
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| Přispěvatelé: | Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), CHI Poissy-Saint-Germain, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), École nationale vétérinaire - Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Gestionnaire, HAL Sorbonne Université 5 |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Genetically modified mouse Infertility Down syndrome medicine.medical_specialty DYRK1A Transgene [SDV.GEN] Life Sciences [q-bio]/Genetics Protein Serine-Threonine Kinases QH426-470 Article Mice 03 medical and health sciences 0302 clinical medicine Hypogonadotropic hypogonadism Internal medicine Testis Genetics medicine Animals Spermatogenesis Zebrafish Infertility Male Genetics (clinical) 030304 developmental biology 0303 health sciences [SDV.GEN]Life Sciences [q-bio]/Genetics biology Hypogonadism Protein-Tyrosine Kinases biology.organism_classification medicine.disease Up-Regulation Mice Inbred C57BL Endocrinology infertility 030217 neurology & neurosurgery |
| Zdroj: | Genes Genes, MDPI, 2021, 12 (11), pp.1800. ⟨10.3390/genes12111800⟩ Genes, 2021, 12 (11), pp.1800. ⟨10.3390/genes12111800⟩ Volume 12 Issue 11 Genes, Vol 12, Iss 1800, p 1800 (2021) |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes12111800⟩ |
| Popis: | International audience; Down syndrome (DS) is the most common chromosomal disorder. It is responsible for intellectual disability (ID) and several medical conditions. Although men with DS are thought to be infertile, some spontaneous paternities have been reported. The few studies of the mechanism of infertility in men with DS are now dated. Recent research in zebrafish has indicated that overexpression of DYRK1A (the protein primarily responsible for ID in DS) impairs gonadogenesis at the embryonic stage. To better ascertain DYRK1A’s role in infertility in DS, we investigated the effect of DYRK1A overexpression in a transgenic mouse model. We found that overexpression of DYRK1A impairs fertility in transgenic male mice. Interestingly, the mechanism in mice differs slightly from that observed in zebrafish but, with disruption of the early stages of spermatogenesis, is similar to that seen in humans. Unexpectedly, we observed hypogonadotropic hypogonadism in the transgenic mice. |
| Databáze: | OpenAIRE |
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