Dermatologic Disorders Associated With Chronic Hepatitis C: Effect of Interferon Therapy
| Autor: | David R. Berk, Susan B. Mallory, Emmet B. Keeffe, Aijaz Ahmed |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Porphyria Cutanea Tarda
Hepatitis C virus medicine.disease_cause Antiviral Agents Skin Diseases Virus Interferon medicine Humans Rheumatoid factor Porphyria cutanea tarda skin and connective tissue diseases Adverse effect Hepatology business.industry Polyarteritis nodosa Lichen Planus Gastroenterology virus diseases Hepatitis C Chronic medicine.disease Clinical trial Cryoglobulinemia Immunology Interferons business medicine.drug |
| Zdroj: | Clinical Gastroenterology and Hepatology. 5:142-151 |
| ISSN: | 1542-3565 |
| Popis: | Chronic hepatitis C virus infection (HCV) is associated with extrahepatic manifestations, including such dermatologic conditions as mixed cryoglobulinemia, porphyria cutanea tarda, and lichen planus. Patients with chronic HCV and extrahepatic manifestations are often excluded from clinical trials evaluating interferon (IFN) therapy due to concerns about poor response, adverse events, and toxicity. Thus, data regarding the efficacy of IFN not only on the underlying chronic HCV, but also on extrahepatic manifestations, are limited in these patients. Case reports suggest that the response of dermatologic extrahepatic manifestations to IFN in patients with chronic HCV is highly variable. This review summarizes available data on dermatologic conditions associated with chronic HCV and their response to IFN therapy. |
| Databáze: | OpenAIRE |
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