| Autor: |
Puneet Jain, Jitendra K. Sahu, Paul S. Horn, Vann Chau, Cristina Go, Quenby Mahood, Ravindra Arya |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Developmental medicine and child neurologyREFERENCES. 64(11) |
| ISSN: |
1469-8749 |
| Popis: |
We performed a systematic review and network meta-analysis (NMA) to obtain comparative effectiveness estimates and rankings of non-surgical interventions used to treat infantile spasms.All randomized controlled trials (RCTs) including children 2 months to 3 years of age with infantile spasms (with hypsarrhythmia or hypsarrhythmia variants on electroencephalography) receiving appropriate first-line medical treatment were included. Electroclinical and clinical remissions within 1 month of starting treatment were analyzed.Twenty-two RCTs comparing first-line treatments for infantile spasms were reviewed; of these, 17 were included in the NMA. Both frequentist and Bayesian network rankings for electroclinical remission showed that high dose adrenocorticotropic hormone (ACTH), methylprednisolone, low dose ACTH and magnesium sulfate (MgSOTreatments including ACTH and high dose prednisolone are more effective in achieving electroclinical and clinical remissions for infantile spasms.Adrenocorticotropic hormone and high dose prednisolone are more effective than other medications for infantile spasms. Symptomatic etiology decreases the likelihood of remission even after adjusting for treatment lag. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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