Effect of Glucocorticosteroids in Diamond-Blackfan Anaemia: Maybe Not as Elusive as It Seems
| Autor: | Marian Hajduch, Zuzana Maceckova, Juan De Sanctis, Agata Kubickova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Catalysis Inorganic Chemistry c-myc GATA1 hemic and lymphatic diseases Humans Erythropoiesis Gene Regulatory Networks Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Glucocorticoids Spectroscopy Anemia Diamond-Blackfan Organic Chemistry General Medicine Diamond-Blackfan anaemia Computer Science Applications Chemistry Treatment Outcome Gene Expression Regulation mTOR glucocorticosteroid hormones hormone substitutes and hormone antagonists |
| Zdroj: | International Journal of Molecular Sciences, Vol 23, Iss 1886, p 1886 (2022) |
| ISSN: | 1422-0067 |
| Popis: | Diamond-Blackfan anaemia (DBA) is a red blood cell aplasia that in the majority of cases is associated with ribosomal protein (RP) aberrations. However, the mechanism by which this disorder leads to such a specific phenotype remains unclear. Even more elusive is the reason why non-specific agents such as glucocorticosteroids (GCs), also known as glucocorticoids, are an effective therapy for DBA. In this review, we (1) explore why GCs are successful in DBA treatment, (2) discuss the effect of GCs on erythropoiesis, and (3) summarise the GC impact on crucial pathways deregulated in DBA. Furthermore, we show that GCs do not regulate DBA erythropoiesis via a single mechanism but more likely via several interdependent pathways. |
| Databáze: | OpenAIRE |
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