Review: Human trophoblast fusion and differentiation: Lessons from trisomy 21 placenta
| Autor: | N. Segond, Pascale Gerbaud, Thierry Fournier, Jean Guibourdenche, D. Evain-Brion, Josette Badet, Melanie Cocquebert, Guillaume Pidoux |
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| Přispěvatelé: | Pidoux, Guillaume, La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus (UMR_S 767), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), PremUp Foundation, Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2012 |
| Předmět: |
Glycosylation
Placenta [SDV]Life Sciences [q-bio] Cellular differentiation Intrauterine growth restriction Cell Communication Pregnancy Proteins Chorionic Gonadotropin Cell Fusion 0302 clinical medicine Pregnancy Cells Cultured reproductive and urinary physiology 0303 health sciences [SDV.BDLR.RS] Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction 030219 obstetrics & reproductive medicine Cell fusion Gene Expression Regulation Developmental Obstetrics and Gynecology Cell Differentiation Receptors LH Trophoblasts 3. Good health Cell biology [SDV] Life Sciences [q-bio] medicine.anatomical_structure embryonic structures Female Signal Transduction [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Cell Line [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction 03 medical and health sciences Syncytiotrophoblast medicine Humans [SDV.BC] Life Sciences [q-bio]/Cellular Biology [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology 030304 developmental biology Trophoblast Placentation [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology medicine.disease Oxidative Stress Reproductive Medicine Immunology Down Syndrome Trisomy Protein Processing Post-Translational Developmental Biology |
| Zdroj: | Placenta Placenta, 2012, 33, Suppl:S81-86. ⟨10.1016/j.placenta.2011.11.007⟩ Placenta, Elsevier, 2012, 33, Suppl:S81-86. ⟨10.1016/j.placenta.2011.11.007⟩ |
| ISSN: | 0143-4004 |
| Popis: | International audience; The syncytiotrophoblast layer plays a major role throughout pregnancy, since it is the site of numerous placental functions, including ion and nutrient exchange and the synthesis of steroid and peptide hormones required for fetal growth and development. Inadequate formation and regeneration of this tissue contributes to several pathologies of pregnancy such as intrauterine growth restriction and preeclampsia, which may lead to iatrogenic preterm delivery in order to prevent fetal death and maternal complications. Syncytiotrophoblast formation can be reproduced in vitro using different models. For the last ten years we have routinely purified villous cytotrophoblastic cells (CT) from normal first, second and third trimester placentas and from gestational age-matched Trisomy 21 placentas. We cultured villous CT on plastic dishes to follow the molecular and biochemical aspects of their morphological and functional differentiation. Taking advantage of this unique collection of samples, we here discuss the concept that trophoblast fusion and functional differentiation may be two differentially regulated processes, which are linked but quite distinct. We highlight the major role of mesenchymal-trophoblast cross talk in regulating trophoblast cell fusion. We suggest that the oxidative status of the trophoblast may regulate glycosylation of proteins, including hCG, and thereby modulate major trophoblast cell functions. |
| Databáze: | OpenAIRE |
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