Impaired renal clearance among Swedish adolescents born preterm
| Autor: | Carin Skogastierna, Anders Elfvin, Sverker Hansson, Per Magnusson, Diana Swolin‐Eide |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Sweden Adolescent Infant Newborn Parturition Infant adolescent kidney function tests extremely preterm infant neonatology nephrology Pediatrik Blood Pressure Gestational Age General Medicine Kidney Function Tests Pediatrics Pregnancy Pediatrics Perinatology and Child Health Humans Female Child Edetic Acid |
| Popis: | Aim To determine whether adolescents born before 28 gestational weeks have an increased risk for renal impairment. Methods Swedish infants, born before 28 gestational weeks in 2001 and 2002, were identified from a local register. A total of 16 children, 12 females and 4 males, were examined at 16-17 years of age with Cr-51-EDTA clearance. A comparison group (n = 26) was used. Results Most study participants (n = 13) had normal blood pressure; one individual had hypertension stage 1. All study participants had results within the reference interval for ionised calcium, parathyroid hormone, intact fibroblast growth factor-23 and for urinary albumin-to-creatinine ratio. Four out of 16 participants (25%) had a Cr-51-EDTA clearance less than 90 ml/min/1.73 m(2), indicating a reduced kidney function. Measured Cr-51-EDTA clearance values were significantly lower in the study group than in the comparison group (p = 0.0012). Five study participants (31%) were referred for further investigations. Conclusion Swedish children born before 28 gestational weeks have an increased risk of renal impairment later in life, suggesting that the kidney function in these individuals should be assessed, at least once, during adolescence. Funding Agencies|Swedish government; county councils [ALFGBG-716831, ALFGBG-678871]; ALF grants from Region Ostergotland; Agrenska research foundation |
| Databáze: | OpenAIRE |
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