Changes in seizure activity of the neocortex during the early postnatal development of the rat: an electrophysiological study on slices in Mg(2+)-free medium
| Autor: | I. Tarnawa, Ildikó Világi, Ilona Banczerowski-Pelyhe |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Aging N-Methylaspartate In Vitro Techniques Somatosensory system Epilepsy Seizures Internal medicine medicine Animals Ketamine Magnesium Electrodes Cerebral Cortex Neocortex Chemistry Somatosensory Cortex medicine.disease Culture Media Rats Electrophysiology Perfusion medicine.anatomical_structure Endocrinology nervous system Neurology Cerebral cortex NMDA receptor Neurology (clinical) Neuroscience medicine.drug |
| Zdroj: | Epilepsy research. 8(2) |
| ISSN: | 0920-1211 |
| Popis: | NMDA receptor-mediated process of rat neocortex slices prepared from 2-24-day-old rats were studied in Mg(2+)-free solution. The response to NMDA application as well as the susceptibility to epileptiform discharges showed age-dependent changes during the first 4 weeks. Slices from the youngest age group seemed to be the most sensitive to NMDA, whereas epileptic activity developed most readily at around the third week. |
| Databáze: | OpenAIRE |
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