Mutagenicity and antimutagenicity of six Brazilian Byrsonima species assessed by the Ames test
| Autor: | Flávia Aparecida Resende, Eliana Aparecida Varanda, Mariana Santoro de Camargo, Catarine Haidê Nogueira, José de Sousa Lima Neto, Rone Aparecido De Grandis, Paula Karina Boldrin, Lourdes Campaner dos Santos, Wagner Vilegas, Lívia Greghi Espanha |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Salmonella typhimurium
Salmonella Antioxidant medicine.medical_treatment medicine.disease_cause Chemoprevention Malpighiaceae Ames test Medicinal plants Botany medicine Plants Medicinal biology Traditional medicine Plant Extracts food and beverages Antimutagenic Agents General Medicine Plants Antimicrobial biology.organism_classification Plant Leaves Complementary and alternative medicine Byrsonima Salmonella/microsome assay Brazil Research Article Mutagens |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP BMC Complementary and Alternative Medicine |
| Popis: | Made available in DSpace on 2014-12-03T13:11:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-05Bitstream added on 2014-12-03T13:22:28Z : No. of bitstreams: 1 WOS000337323000001.pdf: 208097 bytes, checksum: 7dbd1fa211c5c39ca748f25fe1e66c3e (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Background: In various regions of Brazil, several species of the genus Byrsonima (Malpighiaceae) are widely used to treat gastrointestinal complications. This genus has about 150 species of shrubs and trees distributed over the entire Neotropical region. Various biological activities have been identified in these plants, especially antioxidant, antimicrobial and topical and systemic anti-inflammatory activities. The aim of this study was to investigate the mutagenicity and antimutagenicity of hydroalcoholic leaf extracts of six species of Byrsonima: B. verbascifolia, B. correifolia, B. coccolobifolia, B. ligustrifolia, B. fagifolia and B. intermedia by the Salmonella microsome assay (Ames test).Methods: Mutagenic and antimutagenic activity was assessed by the Ames test, with the Salmonella typhimurium tester strains TA100, TA98, TA97a and TA102, with (+S9) and without (-S9) metabolization, by the preincubation method.Results: Only B. coccolobifolia and B. ligustrifolia showed mutagenic activity. However, the extracts of B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia were found to be strongly antimutagenic against at least one of the mutagens tested.Conclusions: These results contribute to valuable data on the safe use of medicinal plants and their potential chemopreventive effects. Considering the excellent antimutagenic activities extracted from B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia, these extracts are good candidate sources of chemopreventive agents. However, B. coccolobifolia and B. ligustrifolia showed mutagenic activity, suggesting caution in their use. UNESP Sao Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 Sao Paulo, Brazil UNESP Sao Paulo State Univ, Chem Inst Araraquara, Dept Organ Chem, BR-14800900 Sao Paulo, Brazil UNESP Sao Paulo State Univ, Unidade Sao Vicente, BR-11330900 Sao Paulo, Brazil UNESP Sao Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 Sao Paulo, Brazil UNESP Sao Paulo State Univ, Chem Inst Araraquara, Dept Organ Chem, BR-14800900 Sao Paulo, Brazil UNESP Sao Paulo State Univ, Unidade Sao Vicente, BR-11330900 Sao Paulo, Brazil |
| Databáze: | OpenAIRE |
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