Development of a multicentre automated model to reduce planning variability in radiotherapy of prostate cancer
| Autor: | Loretta Marr, Phillip Moloney, Peter Griffin, Colin Hornby, Prabhakar Ramachandran, Liam Jukes, Susan Hoyle, Vanessa Panettieri, Cathy Markham, Nigel Cristofaro, Amanda Smith, Sisira Herath, Tomas Kron, Janet Gawthrop, Adam Chapman, Flavio Enrico Nelli, David Ball |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty lcsh:R895-920 medicine.medical_treatment lcsh:RC254-282 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate medicine Arc therapy Radiology Nuclear Medicine and imaging Medical physics Original Research Article Radiation treatment planning Contouring Radiation business.industry Patient survival lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Radiation therapy Clinical Practice medicine.anatomical_structure 030220 oncology & carcinogenesis business |
| Zdroj: | Physics and Imaging in Radiation Oncology, Vol 11, Iss, Pp 34-40 (2019) Physics and Imaging in Radiation Oncology |
| ISSN: | 2405-6316 |
| DOI: | 10.1016/j.phro.2019.07.005 |
| Popis: | Background and purpose Inter-institutional studies highlighted correlation between consistent radiotherapy quality and improved overall patient survival. In treatment planning automation has the potential to address differences due to user-experience and training, promoting standardisation. The aim of this study was to evaluate implementation and clinical effect of a multicentre collaboratively-developed automated planning model for Intensity-Modulated Radiation Therapy/Volumetric-Modulated Arc Therapy of prostate. The model was built using a variety of public institutions’ clinical plans, incorporating different contouring and dose protocols, aiming at minimising their variation. Methods and materials A model using 110 clinically approved and treated prostate plans provided by different radiotherapy centres was built with RapidPlan (RP), for use on intact and post-prostatectomy prostate cases. The model was validated, distributed and introduced into clinical practice in all institutions. To investigate its impact a total of 126 patients, originally manually inverse planned (OP), were replanned using RP without additional planner manual intervention. Target and organ-at-risk (OAR) metrics were statistically compared between original and automated plans. Results For all centres combined and individually, RP provided plans comparable or superior to OP for all dose metrics. Statistically significant reductions with RP were found in bladder (V40Gy) and rectal (V50Gy) low doses (within 2.3% and 3.4% for combined and 4% and 10% individually). No clinically significant changes were seen for the PTV, independently of seminal vesicle inclusion. Conclusion This project showed it is feasible to develop, share and implement RP models created with plans from different institutions treated with a variety of techniques and dose protocols, with the potential of improving treatment planning results and/or efficiency despite the original variability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|