Value of fractional exhaled nitric oxide (FE NO) for the diagnosis of pulmonary involvement due to inflammatory bowel disease
| Autor: | Serpil Akten, Haluk Turktas, Bilge Tunc, Gonca Erbaş, Candan Tuncer, Ezgi Ozyilmaz, Beytullah Yildirim, I. Kivilcim Oguzulgen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty Physical examination Nitric Oxide Inflammatory bowel disease Asymptomatic Gastroenterology Pulmonary function testing Young Adult Crohn Disease DLCO Internal medicine medicine Immunology and Allergy Humans Prospective Studies Prospective cohort study Aged medicine.diagnostic_test business.industry respiratory system Middle Aged medicine.disease Ulcerative colitis digestive system diseases Surgery Respiratory Function Tests Breath Tests Exhalation Case-Control Studies Exhaled nitric oxide Colitis Ulcerative Female medicine.symptom business |
| Zdroj: | Inflammatory bowel diseases. 16(4) |
| ISSN: | 1536-4844 |
| Popis: | Background: Pulmonary involvement due to inflammatory bowel disease (IBD) is frequent when evaluating a patient with IBD and pulmonary involvement remains complicated. Most of the patients are asymptomatic and the methods used are mostly invasive or expensive procedures. The aim of this prospective study is to evaluate the value of the fractional exhaled nitric oxide (FENO) level for the diagnosis of pulmonary involvement due to IBD and to investigate any correlation between FENO level and disease activity. Methods: Thirty-three nonsmoker patients with IBD (25 ulcerative colitis [UC] and 8 Crohn's Disease [CD]) who were free of corticosteroid treatment and 25 healthy subjects as a control group were enrolled in this study. All patients with IBD were investigated for pulmonary involvement with medical history, physical examination, chest roentgenogram, oxygen saturation, blood eosinophil levels, pulmonary function tests (PFTs), high-resolution computed tomography (HRCT), and FENO level. Results: Pulmonary involvement was established in 15 patients (45.5%) with IBD. The FENO level was higher in patients with pulmonary involvement than without pulmonary involvement and healthy controls independent from the pulmonary symptoms, eosinophil count, duration of disease, activity of disease, and surgery history (FENO: 32 ± 20; 24 ± 8; 14 ± 8 ppb, respectively) (P < 0.05). In addition, diffusion capacity (DLCO) was found to be significantly lower in patients with CD compared with UC (P < 0.05). Conclusions: This study showed that an increased FENO level may be used for identifying patients with IBD who need further pulmonary evaluation. Inflamm Bowel Dis 2009 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text