Single dose of mirtazapine modulates whole-brain functional connectivity during emotional narrative processing
| Autor: | K. Meskanen, Erkki Isometsä, Jari Lahti, Roope Heikkilä, Tuukka T. Raij, Enrico Glerean, Jesper Ekelund, Tarja Melartin, Lauri Nummenmaa, Pekka Jylhä, E. Komulainen |
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| Přispěvatelé: | Clinicum, Department of Psychiatry, Helsinki Collegium for Advanced Studies, Medicum, Department of Psychology and Logopedics, HUS Psychiatry, Developmental Psychology Research Group |
| Rok vydání: | 2016 |
| Předmět: |
Male
NEURONAL RESPONSES Emotions Antidepressant PREFRONTAL CORTEX Brain mapping 3124 Neurology and psychiatry Developmental psychology FACE EMOTIONS 0302 clinical medicine Information processing Prefrontal cortex MOTOR CORTEX MAJOR DEPRESSIVE DISORDER NEURAL SYSTEMS Brain Mapping Narration medicine.diagnostic_test fMRI Brain Fear Magnetic Resonance Imaging 3. Good health Psychiatry and Mental health CITALOPRAM Female Psychology Arousal medicine.drug Adult 515 Psychology Mirtazapine Neuroscience (miscellaneous) Mianserin ta3112 03 medical and health sciences Young Adult medicine Humans Radiology Nuclear Medicine and imaging Valence (psychology) Adrenergic alpha-Antagonists Dynamic functional connectivity Emotion 3112 Neurosciences SELECTIVE SEROTONIN ta3124 Neural network 030227 psychiatry Nerve Net Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery HEALTHY-VOLUNTEERS |
| Zdroj: | Psychiatry research. Neuroimaging. 263 |
| ISSN: | 1872-7506 |
| Popis: | The link between neurotransmitter-level effects of antidepressants and their clinical effect remain poorly understood. A single dose of mirtazapine decreases limbic responses to fearful faces in healthy subjects, but it is unknown whether this effect applies to complex emotional situations and dynamic connectivity between brain regions. Thirty healthy volunteers listened to spoken emotional narratives during functional magnetic resonance imaging (fMRI). In an open-label design, 15 subjects received 15 mg of mirtazapine two hours prior to fMRI while 15 subjects served as a control group. We assessed the effects of mirtazapine on regional neural responses and dynamic functional connectivity associated with valence and arousal. Mirtazapine attenuated responses to unpleasant events in the right fronto-insular cortex, while modulating responses to arousing events in the core limbic regions and the cortical midline structures (CMS). Mirtazapine decreased responses to unpleasant and arousing events in sensorimotor areas and the anterior CMS implicated in self-referential processing and formation of subjective feelings. Mirtazapine increased functional connectivity associated with positive valence in the CMS and limbic regions. Mirtazapine triggers large-scale changes in regional responses and functional connectivity during naturalistic, emotional stimuli. These span limbic, sensorimotor, and midline brain structures, and may be relevant to the clinical effectiveness of mirtazapine. |
| Databáze: | OpenAIRE |
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