Dosimetric characterisation and application to radiation biology of a kHz laser-driven electron beam
| Autor: | Aline Vernier, Rachel Delorme, Patrik Gonçalves Jorge, Lucas Rovige, M. Cavallone, Raphaël Moeckli, Emilie Bayart, Jérôme Faure, Eric Deutsch, Alessandro Flacco, Julius Huijts |
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| Přispěvatelé: | Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Lausanne University Hospital, Institut Gustave Roussy (IGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Accelerator Physics (physics.acc-ph)
Materials science Radiobiology Physics and Astronomy (miscellaneous) [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph] General Physics and Astronomy FOS: Physical sciences Electron Applied Physics (physics.app-ph) [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine 01 natural sciences law.invention 010309 optics Optics law 0103 physical sciences Dosimetry Irradiation 010306 general physics business.industry General Engineering Physics - Applied Physics Laser 3. Good health Picosecond Femtosecond Cathode ray [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] Physics - Accelerator Physics business |
| Zdroj: | Appl.Phys.B Appl.Phys.B, 2021, 127 (4), pp.57. ⟨10.1007/s00340-021-07610-z⟩ Applied Physics B, vol. 127, no. 4 |
| Popis: | International audience; Laser-plasma accelerators can produce ultra-short electron bunches in the femtosecond to picosecond duration range, resulting in very high peak dose rates in comparison with clinical accelerators. This unique characteristic motivates their possible application to radiation biology studies to elucidate the effect of high peak dose rates and peculiar temporal structures on the biological response of living cells, which might improve the differential response between tumour and healthy tissues. Electron beams driven by kHz laser systems are an attractive option among laser-plasma accelerators since the high repetition rate can boost the mean dose rate and improve the stability of the delivered dose in comparison with J-class laser accelerators running at few Hz. In this work, we present the dosimetric characterisation of a kHz, low energy laser-driven electron source and preliminary results on in-vitro irradiation of cancer cells. A shot-to-shot dosimetry protocol enabled monitoring of the beam stability and the irradiation conditions for each cell sample. Results of survival assays on HCT116 colorectal cancer cells are in good agreement with previous findings reported in the literature and validate the robustness of the dosimetry and irradiation protocol. |
| Databáze: | OpenAIRE |
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