An immunohistologic study of granulomatous inflammation in SIV-infected rhesus monkeys
| Autor: | Prabhat K. Sehgal, Meredith A. Simon, C J Horvath, Douglas J. Ringler, Ronald D. Hunt |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty CD8 Antigens T-Lymphocytes T cell Lymphocyte Freund's Adjuvant Immunology Simian Acquired Immunodeficiency Syndrome Vascular Cell Adhesion Molecule-1 Cell Count Biology medicine.disease_cause Immunophenotyping Antigens CD Lymphadenitis hemic and lymphatic diseases medicine Animals Immunology and Allergy Macrophage In Situ Hybridization Granuloma Cell Biology T lymphocyte Simian immunodeficiency virus Antigens CD20 Immunohistochemistry Macaca mulatta Antigens Differentiation B-Lymphocyte medicine.anatomical_structure Simian AIDS Giant cell CD4 Antigens DNA Viral Simian Immunodeficiency Virus Cell Adhesion Molecules Cell Division CD8 |
| Zdroj: | Journal of Leukocyte Biology. 53:532-540 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1002/jlb.53.5.532 |
| Popis: | We studied granulomatous inflammation in simian AIDS using histologic, immunohistologic, and in situ hybridization techniques. Complete Freund’s adjuvant was used to induce granulomas in two control animals and two macaques infected with simian immunodeficiency virus (SIV) and having low peripheral CD4+ T cell counts. Control animals developed large (>2 cm diameter) epithelioid granulomas containing CD68+ macrophages (mφs), epithelioid mφs and multinucleated giant cells (MNGCs), CD4+ and CD8+ T cells, and small perivascular collections of CD20+ B cells. Lymphocytes rarely expressed proliferating cell nuclear antigen (Ki-67), and only rare endothelial cells expressed vascular cell adhesion molecule 1 (VCAM-1). In contrast, SIV+ animals had smaller ( |
| Databáze: | OpenAIRE |
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