Brief Report: Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D
| Autor: | Uwe Christians, D. Heather Watts, Jelena Klawitter, Risa M Hoffman, Deborah Kacanek, for Impaact P Team, Diane W. Wara, Kunjal Patel, Yanling Huo, Adriana Weinberg |
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| Rok vydání: | 2019 |
| Předmět: |
HIV Infections
Article vitamin D deficiency Pregnancy Vitamin D and neurology Humans Medicine Pharmacology (medical) Pregnancy Complications Infectious Vitamin D business.industry Interleukin-2 Receptor alpha Subunit Gestational age HIV Protease Inhibitors medicine.disease Granulocyte colony-stimulating factor Interleukin 10 Infectious Diseases Immunology Eicosanoids Premature Birth RNA Viral Gestation Female Interleukin 18 business Biomarkers |
| Zdroj: | J Acquir Immune Defic Syndr |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/qai.0000000000002111 |
| Popis: | Background Women living with HIV (WLHIV) have increased risk of spontaneous preterm delivery (SPTD). We sought to identify plasma predictors of SPTD and their correlations with factors that increase the risk of SPTD, such as vitamin D deficiency and use of protease inhibitors. Design Plasma was obtained from 103 WLHIV with SPTD (≤35 weeks gestation) and 205 controls with term deliveries (TDs; ≥37 weeds) matched to cases 2:1 by race and gestational age at blood draw. TNFα, IFNγ, IL6, IL8, IL1β, IL18, IL17, granulocyte colony stimulating factor (GCSF), MCP1, IP10, sIL2Rα, sCD14, vascular endothelial factor a, monocyte colony stimulation factor, GROα, MMP9, IL10, TGFβ, sCTLA4, and eicosanoids were compared between cases adjusting for known SPTD risk factors. Results Participants had similar demographic characteristics, but cases had higher plasma HIV RNA, lower CD4 cells, and more advanced HIV disease compared with controls. High sIL2Rα was associated with increased risk of SPTD. High sCD14, GCSF, PGF2α, and 5-HEPE were marginally associated with increased risk of SPTD. Women who initiated protease inhibitors-containing antiretroviral treatment before or during the first trimester had higher levels of GCSF and 5-HEPE compared with women without such exposure before plasma collection. Vitamin D insufficiency was associated with higher inflammatory sCD14 and PGF2α, and lower anti-inflammatory 5-HEPE. Conclusions The best plasma predictor of SPTD in WLHIV was sIL2Rα, a marker of T-cell activation. Markers of monocyte activation and eicosanoids were marginally increased in WLHIV and SPTD, suggesting that they may also play a role in the pathogenesis of this disorder. |
| Databáze: | OpenAIRE |
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