The pro-convulsant effects of diazinon low dose in male rats under amygdala kindling
| Autor: | Mahdi Mashhadi Akbar Boojar, Farideh Bahrami, Mehdi Saberi, Fatemeh Saberi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Diazinon Health Toxicology and Mutagenesis Convulsants 010501 environmental sciences Pharmacology Toxicology 01 natural sciences Amygdala 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Male rats medicine Kindling Neurologic Animals Rats Wistar 0105 earth and related environmental sciences Chemical Health and Safety Kindling business.industry Low dose Public Health Environmental and Occupational Health food and beverages General Medicine Toxic dose Amygdala kindling Rats medicine.anatomical_structure chemistry Convulsant business 030217 neurology & neurosurgery |
| Zdroj: | Drug and chemical toxicology. 45(2) |
| ISSN: | 1525-6014 |
| Popis: | Organophosphates can damage the brain in systemic intoxication. In this study, the effects of a minimum toxic dose (MTD) of diazinon (DZ) on amygdala afterdischarge threshold (ADT), kindling acquisition and kindled seizure parameters were evaluated. Intact male rats were stereotactically implanted with a tripolar and two monopolar electrodes in the amygdala and dura respectively. After recovery, animals received daily either, olive oil (control), 15 or 30 mg/kg (MTD) of DZ intraperitoneally, and ADT, afterdischarge duration (ADD) at each stage (S |
| Databáze: | OpenAIRE |
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